Inhibitory Effect of the HASPIN Inhibitor CHR-6494 on BxPC-3-Luc, A Luciferase-Expressing Pancreatic Cancer Cell Line

HASPIN acts in chromosome segregation via histone phosphorylation. Recently, HASPIN inhibitors have been shown to suppress growth of various cancer cells. Pancreatic cancer has no symptom in the early stages and may progress before detection. So, the 5-year survival rate is low. Here, we reported th...

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Detalles Bibliográficos
Autores principales: Tanaka, Hiromitsu, Nishida-Fukuda, Hisayo, Wada, Morimasa, Tokuhiro, Keizo, Matsushita, Hiroaki, Ando, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124445/
https://www.ncbi.nlm.nih.gov/pubmed/35674022
http://dx.doi.org/10.22074/cellj.2022.7796
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author Tanaka, Hiromitsu
Nishida-Fukuda, Hisayo
Wada, Morimasa
Tokuhiro, Keizo
Matsushita, Hiroaki
Ando, Yukio
author_facet Tanaka, Hiromitsu
Nishida-Fukuda, Hisayo
Wada, Morimasa
Tokuhiro, Keizo
Matsushita, Hiroaki
Ando, Yukio
author_sort Tanaka, Hiromitsu
collection PubMed
description HASPIN acts in chromosome segregation via histone phosphorylation. Recently, HASPIN inhibitors have been shown to suppress growth of various cancer cells. Pancreatic cancer has no symptom in the early stages and may progress before detection. So, the 5-year survival rate is low. Here, we reported that administration of the HASPIN inhibitor, CHR-6494, to mice bearing pancreatic BxPC-3-Luc cancer cells significantly suppressed growth of BxPC-3-Luc cells. CHR-6494 might be a useful agent for treating pancreatic cancer.
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spelling pubmed-91244452022-06-08 Inhibitory Effect of the HASPIN Inhibitor CHR-6494 on BxPC-3-Luc, A Luciferase-Expressing Pancreatic Cancer Cell Line Tanaka, Hiromitsu Nishida-Fukuda, Hisayo Wada, Morimasa Tokuhiro, Keizo Matsushita, Hiroaki Ando, Yukio Cell J Short Communication HASPIN acts in chromosome segregation via histone phosphorylation. Recently, HASPIN inhibitors have been shown to suppress growth of various cancer cells. Pancreatic cancer has no symptom in the early stages and may progress before detection. So, the 5-year survival rate is low. Here, we reported that administration of the HASPIN inhibitor, CHR-6494, to mice bearing pancreatic BxPC-3-Luc cancer cells significantly suppressed growth of BxPC-3-Luc cells. CHR-6494 might be a useful agent for treating pancreatic cancer. Royan Institute 2022-04 2022-04-27 /pmc/articles/PMC9124445/ /pubmed/35674022 http://dx.doi.org/10.22074/cellj.2022.7796 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited. https://creativecommons.org/licenses/by-nc/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial 3.0 (CC BY-NC 3.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Tanaka, Hiromitsu
Nishida-Fukuda, Hisayo
Wada, Morimasa
Tokuhiro, Keizo
Matsushita, Hiroaki
Ando, Yukio
Inhibitory Effect of the HASPIN Inhibitor CHR-6494 on BxPC-3-Luc, A Luciferase-Expressing Pancreatic Cancer Cell Line
title Inhibitory Effect of the HASPIN Inhibitor CHR-6494 on BxPC-3-Luc, A Luciferase-Expressing Pancreatic Cancer Cell Line
title_full Inhibitory Effect of the HASPIN Inhibitor CHR-6494 on BxPC-3-Luc, A Luciferase-Expressing Pancreatic Cancer Cell Line
title_fullStr Inhibitory Effect of the HASPIN Inhibitor CHR-6494 on BxPC-3-Luc, A Luciferase-Expressing Pancreatic Cancer Cell Line
title_full_unstemmed Inhibitory Effect of the HASPIN Inhibitor CHR-6494 on BxPC-3-Luc, A Luciferase-Expressing Pancreatic Cancer Cell Line
title_short Inhibitory Effect of the HASPIN Inhibitor CHR-6494 on BxPC-3-Luc, A Luciferase-Expressing Pancreatic Cancer Cell Line
title_sort inhibitory effect of the haspin inhibitor chr-6494 on bxpc-3-luc, a luciferase-expressing pancreatic cancer cell line
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124445/
https://www.ncbi.nlm.nih.gov/pubmed/35674022
http://dx.doi.org/10.22074/cellj.2022.7796
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