Steroid-Induced Diabetic Ketoacidosis: A Case Report and Review of the Literature

It has been well documented that corticosteroid treatment can precipitate hyperglycemia and may lead to new diagnoses of type 2 diabetes mellitus. However, steroid-induced diabetic ketoacidosis (DKA) has rarely been reported in the literature. We report the case of an obese 73-year-old man with no known history of diabetes mellitus who presented with DKA after two months of treatment with high-dose steroids. Our patient’s presentation and clinical course were consistent with ketosis-prone type 2 diabetes (KPDM-2). A literature review revealed three other reports of patients with steroid-induced DKA, two of whom also had clinical and biochemical features that were consistent with KPDM-2. We postulate that high-dose steroid treatment can trigger DKA in a subgroup of obese, middle-aged patients with risk factors for KPDM-2. Physicians should suspect steroid-induced KPDM-2 in obese patients who present with new-onset DKA after initiation of steroid treatment.