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Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery

BACKGROUND: Phthalates are used in manufacturing of consumer products, resulting in ubiquitous human exposure to phthalate mixtures. Previous work has suggested that phthalates display endocrine disrupting capabilities, and exposure is associated with early delivery. OBJECTIVE: To assess mediating e...

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Autores principales: Cathey, Amber L., Aung, Max T., Watkins, Deborah J., Rosario, Zaira Y., Vélez Vega, Carmen M., Alshawabkeh, Akram N., Cordero, José F., Mukherjee, Bhramar, Meeker, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124667/
https://www.ncbi.nlm.nih.gov/pubmed/34987188
http://dx.doi.org/10.1038/s41370-021-00408-3
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author Cathey, Amber L.
Aung, Max T.
Watkins, Deborah J.
Rosario, Zaira Y.
Vélez Vega, Carmen M.
Alshawabkeh, Akram N.
Cordero, José F.
Mukherjee, Bhramar
Meeker, John D.
author_facet Cathey, Amber L.
Aung, Max T.
Watkins, Deborah J.
Rosario, Zaira Y.
Vélez Vega, Carmen M.
Alshawabkeh, Akram N.
Cordero, José F.
Mukherjee, Bhramar
Meeker, John D.
author_sort Cathey, Amber L.
collection PubMed
description BACKGROUND: Phthalates are used in manufacturing of consumer products, resulting in ubiquitous human exposure to phthalate mixtures. Previous work has suggested that phthalates display endocrine disrupting capabilities, and exposure is associated with early delivery. OBJECTIVE: To assess mediating effects of hormone concentrations on associations between phthalate mixtures and preterm birth (PTB). METHODS: Repeated urinary phthalates and serum hormones were measured among 1011 women in the PROTECT Puerto Rico birth cohort from 2011–2019. We utilized ridge regression to create phthalate environmental risk scores (ERS), which represent weighted summaries of total phthalate exposure. Mediation analyses were conducted on a subset of 705 women. We additionally conducted fetal sex-specific analyses. RESULTS: Free thyroxine (FT4) mediated 9.6% of the association between high molecular weight (HMW) ERS at 18 weeks and reduced gestational age at delivery (95%CI:1.07–29.9). Progesterone at 26 weeks mediated 21.1% and 16.2% of the association between HMW ERS at 18 and 22 weeks, and spontaneous PTB, respectively. Among male fetuses, corticotropin releasing hormone (CRH) at 18 weeks mediated 28.2% of the association between low molecular weight ERS and spontaneous PTB. SIGNIFICANCE: We provide introductory evidence of hormone disruption on the causal pathway between phthalate exposure and early delivery. We also show differences by fetal sex, but a larger sample size is necessary to validate our findings.
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spelling pubmed-91246672022-07-05 Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery Cathey, Amber L. Aung, Max T. Watkins, Deborah J. Rosario, Zaira Y. Vélez Vega, Carmen M. Alshawabkeh, Akram N. Cordero, José F. Mukherjee, Bhramar Meeker, John D. J Expo Sci Environ Epidemiol Article BACKGROUND: Phthalates are used in manufacturing of consumer products, resulting in ubiquitous human exposure to phthalate mixtures. Previous work has suggested that phthalates display endocrine disrupting capabilities, and exposure is associated with early delivery. OBJECTIVE: To assess mediating effects of hormone concentrations on associations between phthalate mixtures and preterm birth (PTB). METHODS: Repeated urinary phthalates and serum hormones were measured among 1011 women in the PROTECT Puerto Rico birth cohort from 2011–2019. We utilized ridge regression to create phthalate environmental risk scores (ERS), which represent weighted summaries of total phthalate exposure. Mediation analyses were conducted on a subset of 705 women. We additionally conducted fetal sex-specific analyses. RESULTS: Free thyroxine (FT4) mediated 9.6% of the association between high molecular weight (HMW) ERS at 18 weeks and reduced gestational age at delivery (95%CI:1.07–29.9). Progesterone at 26 weeks mediated 21.1% and 16.2% of the association between HMW ERS at 18 and 22 weeks, and spontaneous PTB, respectively. Among male fetuses, corticotropin releasing hormone (CRH) at 18 weeks mediated 28.2% of the association between low molecular weight ERS and spontaneous PTB. SIGNIFICANCE: We provide introductory evidence of hormone disruption on the causal pathway between phthalate exposure and early delivery. We also show differences by fetal sex, but a larger sample size is necessary to validate our findings. 2022-05 2022-01-05 /pmc/articles/PMC9124667/ /pubmed/34987188 http://dx.doi.org/10.1038/s41370-021-00408-3 Text en http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Cathey, Amber L.
Aung, Max T.
Watkins, Deborah J.
Rosario, Zaira Y.
Vélez Vega, Carmen M.
Alshawabkeh, Akram N.
Cordero, José F.
Mukherjee, Bhramar
Meeker, John D.
Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
title Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
title_full Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
title_fullStr Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
title_full_unstemmed Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
title_short Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
title_sort mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124667/
https://www.ncbi.nlm.nih.gov/pubmed/34987188
http://dx.doi.org/10.1038/s41370-021-00408-3
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