Cargando…

Metformin modulates mitochondrial function and mitophagy in peripheral blood mononuclear cells from type 2 diabetic patients

Type 2 diabetes is a chronic metabolic disease that affects mitochondrial function. In this context, the rescue mechanisms of mitochondrial health, such as mitophagy and mitochondrial biogenesis, are of crucial importance. The gold standard for the treatment of type 2 diabetes is metformin, which ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Marañón, Aranzazu M., Díaz-Pozo, Pedro, Canet, Francisco, Díaz-Morales, Noelia, Abad-Jiménez, Zaida, López-Domènech, Sandra, Vezza, Teresa, Apostolova, Nadezda, Morillas, Carlos, Rocha, Milagros, Víctor, Víctor M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124713/ https://www.ncbi.nlm.nih.gov/pubmed/35605453 http://dx.doi.org/10.1016/j.redox.2022.102342

Ejemplares similares

Relationship between PMN-endothelium interactions, ROS production and Beclin-1 in type 2 diabetes
por: De Marañon, Aranzazu M., et al.
Publicado: (2020)

Mitochondrial Alterations and Enhanced Human Leukocyte/Endothelial Cell Interactions in Type 1 Diabetes
por: Iannantuoni, Francesca, et al.
Publicado: (2020)

MicroRNAs and Oxidative Stress: An Intriguing Crosstalk to Be Exploited in the Management of Type 2 Diabetes
por: Vezza, Teresa, et al.
Publicado: (2021)

Association between Proinflammatory Markers, Leukocyte–Endothelium Interactions, and Carotid Intima–Media Thickness in Type 2 Diabetes: Role of Glycemic Control
por: de Marañón, Aranzazu Martinez, et al.
Publicado: (2020)

The Role of Mitochondrial Dynamic Dysfunction in Age-Associated Type 2 Diabetes
por: Vezza, Teresa, et al.
Publicado: (2022)

The Mitochondrial Antioxidant SS-31 Modulates Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Type 2 Diabetes
por: Escribano-López, Irene, et al.
Publicado: (2019)

Does Empagliflozin Modulate Leukocyte–Endothelium Interactions, Oxidative Stress, and Inflammation in Type 2 Diabetes?
por: Canet, Francisco, et al.
Publicado: (2021)

Impact of Roux-en-Y Gastric Bypass on Mitochondrial Biogenesis and Dynamics in Leukocytes of Obese Women
por: Abad-Jiménez, Zaida, et al.
Publicado: (2022)

Roux-en-Y Gastric Bypass Modulates AMPK, Autophagy and Inflammatory Response in Leukocytes of Obese Patients
por: Abad-Jiménez, Zaida, et al.
Publicado: (2022)

Phytosterols: Nutritional Health Players in the Management of Obesity and Its Related Disorders
por: Vezza, Teresa, et al.
Publicado: (2020)

Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity
por: López-Domènech, Sandra, et al.
Publicado: (2018)

Systemic Oxidative Stress and Visceral Adipose Tissue Mediators of NLRP3 Inflammasome and Autophagy Are Reduced in Obese Type 2 Diabetic Patients Treated with Metformin
por: Abad-Jiménez, Zaida, et al.
Publicado: (2020)

Mitochondrial redox impairment and enhanced autophagy in peripheral blood mononuclear cells from type 1 diabetic patients
por: Canet, F., et al.
Publicado: (2022)

Effect of Roux-en-Y Bariatric Bypass Surgery on Subclinical Atherosclerosis and Oxidative Stress Markers in Leukocytes of Obese Patients: A One-Year Follow-Up Study
por: Abad-Jiménez, Zaida, et al.
Publicado: (2020)

The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes
por: Escribano-Lopez, Irene, et al.
Publicado: (2018)

Gold Nanoparticles Supported on Ceria Nanoparticles Modulate Leukocyte–Endothelium Cell Interactions and Inflammation in Type 2 Diabetes
por: Díaz-Pozo, Pedro, et al.
Publicado: (2022)

Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes
por: Vezza, Teresa, et al.
Publicado: (2020)

Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions
por: Apostolova, Nadezda, et al.
Publicado: (2020)

The SGLT2 Inhibitor Empagliflozin Ameliorates the Inflammatory Profile in Type 2 Diabetic Patients and Promotes an Antioxidant Response in Leukocytes
por: Iannantuoni, Francesca, et al.
Publicado: (2019)

Mitochondrial DNA Haplogroup JT is Related to Impaired Glycaemic Control and Renal Function in Type 2 Diabetic Patients
por: Diaz-Morales, Noelia, et al.
Publicado: (2018)

Relationship between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues
por: Burgos-Morón, Estefania, et al.
Publicado: (2019)

PGK1-AR axis: Benefits of a novel actor in PCOS pathology
por: Vezza, Teresa, et al.
Publicado: (2020)

Effects of GLP-1 receptor agonists on mitochondrial function, inflammatory markers and leukocyte-endothelium interactions in type 2 diabetes
por: Luna-Marco, Clara, et al.
Publicado: (2023)

Characterization of Differentially Expressed Circulating miRNAs in Metabolically Healthy versus Unhealthy Obesity
por: Rovira-Llopis, Susana, et al.
Publicado: (2021)

Effect of Non-Surgical Periodontal Treatment on Oxidative Stress Markers in Leukocytes and Their Interaction with the Endothelium in Obese Subjects with Periodontitis: A Pilot Study
por: Martínez-Herrera, Mayte, et al.
Publicado: (2020)

Insulin Resistance in PCOS Patients Enhances Oxidative Stress and Leukocyte Adhesion: Role of Myeloperoxidase
por: Victor, Victor M., et al.
Publicado: (2016)

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications
por: Rovira-Llopis, Susana, et al.
Publicado: (2017)

The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated from type 2 diabetic patients
por: Escribano-Lopez, Irene, et al.
Publicado: (2016)

Down-Regulation of the Longevity-Associated Protein SIRT1 in Peripheral Blood Mononuclear Cells of Treated HIV Patients
por: Gruevska, Aleksandra, et al.
Publicado: (2022)

The PINK1—Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells
por: Bradshaw, Aaron V., et al.
Publicado: (2021)

Malnutrition impairs mitochondrial function and leukocyte activation
por: Bañuls, Celia, et al.
Publicado: (2019)

Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53
por: Song, Young Mi, et al.
Publicado: (2016)

Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women
por: Pradas, Irene, et al.
Publicado: (2019)

GRP78 Overexpression Triggers PINK1-IP(3)R-Mediated Neuroprotective Mitophagy
por: Leiva-Rodríguez, Tatiana, et al.
Publicado: (2021)

Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease
por: Cordero, Mario D, et al.
Publicado: (2010)

mRNA expression analysis of the SUMO pathway genes in the adult mouse retina
por: Abad-Morales, Víctor, et al.
Publicado: (2015)

Correction: Association of Serum Retinol Binding Protein 4 with Atherogenic Dyslipidemia in Morbid Obese Patients
por: Rocha, Milagros, et al.
Publicado: (2013)

Association of Serum Retinol Binding Protein 4 with Atherogenic Dyslipidemia in Morbid Obese Patients
por: Rocha, Milagros, et al.
Publicado: (2013)

Metformin upregulates mitophagy in patients with T2DM: A randomized placebo‐controlled study
por: Bhansali, Shipra, et al.
Publicado: (2020)

The HIF1α-PFKFB3 Pathway: A Key Player in Diabetic Retinopathy
por: Vezza, Teresa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_umsgphlg7c0grva932h0bbkbv6