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Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis
The resolution of inflammation is a temporally and spatially coordinated process that in its innate manifestations, primarily involves neutrophils and macrophages. The shutdown of infection or injury-induced acute inflammation requires termination of neutrophil accumulation within the affected sites...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124752/ https://www.ncbi.nlm.nih.gov/pubmed/35615359 http://dx.doi.org/10.3389/fimmu.2022.863449 |
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author | Silberberg, Esther Filep, János G. Ariel, Amiram |
author_facet | Silberberg, Esther Filep, János G. Ariel, Amiram |
author_sort | Silberberg, Esther |
collection | PubMed |
description | The resolution of inflammation is a temporally and spatially coordinated process that in its innate manifestations, primarily involves neutrophils and macrophages. The shutdown of infection or injury-induced acute inflammation requires termination of neutrophil accumulation within the affected sites, neutrophil demise, and clearance by phagocytes (efferocytosis), such as tissue-resident and monocyte-derived macrophages. This must be followed by macrophage reprogramming from the inflammatory to reparative and consequently resolution-promoting phenotypes and the production of resolution-promoting lipid and protein mediators that limit responses in various cell types and promote tissue repair and return to homeostatic architecture and function. Recent studies suggest that these events, and macrophage reprogramming to pro-resolving phenotypes in particular, are not only important in the acute setting, but might be paramount in limiting chronic inflammation, autoimmunity, and various uncontrolled cytokine-driven pathologies. The SARS-CoV-2 (COVID-19) pandemic has caused a worldwide health and economic crisis. Severe COVID-19 cases that lead to high morbidity are tightly associated with an exuberant cytokine storm that seems to trigger shock-like pathologies, leading to vascular and multiorgan failures. In other cases, the cytokine storm can lead to diffuse alveolar damage that results in acute respiratory distress syndrome (ARDS) and lung failure. Here, we address recent advances on effectors in the resolution of inflammation and discuss how pro-resolution mechanisms with particular emphasis on macrophage reprogramming, might be harnessed to limit the universal COVID-19 health threat. |
format | Online Article Text |
id | pubmed-9124752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91247522022-05-24 Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis Silberberg, Esther Filep, János G. Ariel, Amiram Front Immunol Immunology The resolution of inflammation is a temporally and spatially coordinated process that in its innate manifestations, primarily involves neutrophils and macrophages. The shutdown of infection or injury-induced acute inflammation requires termination of neutrophil accumulation within the affected sites, neutrophil demise, and clearance by phagocytes (efferocytosis), such as tissue-resident and monocyte-derived macrophages. This must be followed by macrophage reprogramming from the inflammatory to reparative and consequently resolution-promoting phenotypes and the production of resolution-promoting lipid and protein mediators that limit responses in various cell types and promote tissue repair and return to homeostatic architecture and function. Recent studies suggest that these events, and macrophage reprogramming to pro-resolving phenotypes in particular, are not only important in the acute setting, but might be paramount in limiting chronic inflammation, autoimmunity, and various uncontrolled cytokine-driven pathologies. The SARS-CoV-2 (COVID-19) pandemic has caused a worldwide health and economic crisis. Severe COVID-19 cases that lead to high morbidity are tightly associated with an exuberant cytokine storm that seems to trigger shock-like pathologies, leading to vascular and multiorgan failures. In other cases, the cytokine storm can lead to diffuse alveolar damage that results in acute respiratory distress syndrome (ARDS) and lung failure. Here, we address recent advances on effectors in the resolution of inflammation and discuss how pro-resolution mechanisms with particular emphasis on macrophage reprogramming, might be harnessed to limit the universal COVID-19 health threat. Frontiers Media S.A. 2022-05-09 /pmc/articles/PMC9124752/ /pubmed/35615359 http://dx.doi.org/10.3389/fimmu.2022.863449 Text en Copyright © 2022 Silberberg, Filep and Ariel https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Silberberg, Esther Filep, János G. Ariel, Amiram Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis |
title | Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis |
title_full | Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis |
title_fullStr | Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis |
title_full_unstemmed | Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis |
title_short | Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis |
title_sort | weathering the storm: harnessing the resolution of inflammation to limit covid-19 pathogenesis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124752/ https://www.ncbi.nlm.nih.gov/pubmed/35615359 http://dx.doi.org/10.3389/fimmu.2022.863449 |
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