Cargando…
Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action
Inflammation often develops from acute, chronic, or auto-inflammatory disorders that can lead to compromised organ function. Cannabis (Cannabis sativa) has been used to treat inflammation for millennia, but its use in modern medicine is hampered by a lack of scientific knowledge. Previous studies re...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124761/ https://www.ncbi.nlm.nih.gov/pubmed/35614947 http://dx.doi.org/10.3389/fphar.2022.908198 |
_version_ | 1784711794130944000 |
---|---|
author | Anil, Seegehalli M. Peeri, Hadar Koltai, Hinanit |
author_facet | Anil, Seegehalli M. Peeri, Hadar Koltai, Hinanit |
author_sort | Anil, Seegehalli M. |
collection | PubMed |
description | Inflammation often develops from acute, chronic, or auto-inflammatory disorders that can lead to compromised organ function. Cannabis (Cannabis sativa) has been used to treat inflammation for millennia, but its use in modern medicine is hampered by a lack of scientific knowledge. Previous studies report that cannabis extracts and inflorescence inhibit inflammatory responses in vitro and in pre-clinical and clinical trials. The endocannabinoid system (ECS) is a modulator of immune system activity, and dysregulation of this system is involved in various chronic inflammations. This system includes cannabinoid receptor types 1 and 2 (CB1 and CB2), arachidonic acid-derived endocannabinoids, and enzymes involved in endocannabinoid metabolism. Cannabis produces a large number of phytocannabinoids and numerous other biomolecules such as terpenes and flavonoids. In multiple experimental models, both in vitro and in vivo, several phytocannabinoids, including Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabigerol (CBG), exhibit activity against inflammation. These phytocannabinoids may bind to ECS and/or other receptors and ameliorate various inflammatory-related diseases by activating several signaling pathways. Synergy between phytocannabinoids, as well as between phytocannabinoids and terpenes, has been demonstrated. Cannabis activity can be improved by selecting the most active plant ingredients (API) while eliminating parts of the whole extract. Moreover, in the future cannabis components might be combined with pharmaceutical drugs to reduce inflammation. |
format | Online Article Text |
id | pubmed-9124761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91247612022-05-24 Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action Anil, Seegehalli M. Peeri, Hadar Koltai, Hinanit Front Pharmacol Pharmacology Inflammation often develops from acute, chronic, or auto-inflammatory disorders that can lead to compromised organ function. Cannabis (Cannabis sativa) has been used to treat inflammation for millennia, but its use in modern medicine is hampered by a lack of scientific knowledge. Previous studies report that cannabis extracts and inflorescence inhibit inflammatory responses in vitro and in pre-clinical and clinical trials. The endocannabinoid system (ECS) is a modulator of immune system activity, and dysregulation of this system is involved in various chronic inflammations. This system includes cannabinoid receptor types 1 and 2 (CB1 and CB2), arachidonic acid-derived endocannabinoids, and enzymes involved in endocannabinoid metabolism. Cannabis produces a large number of phytocannabinoids and numerous other biomolecules such as terpenes and flavonoids. In multiple experimental models, both in vitro and in vivo, several phytocannabinoids, including Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabigerol (CBG), exhibit activity against inflammation. These phytocannabinoids may bind to ECS and/or other receptors and ameliorate various inflammatory-related diseases by activating several signaling pathways. Synergy between phytocannabinoids, as well as between phytocannabinoids and terpenes, has been demonstrated. Cannabis activity can be improved by selecting the most active plant ingredients (API) while eliminating parts of the whole extract. Moreover, in the future cannabis components might be combined with pharmaceutical drugs to reduce inflammation. Frontiers Media S.A. 2022-05-09 /pmc/articles/PMC9124761/ /pubmed/35614947 http://dx.doi.org/10.3389/fphar.2022.908198 Text en Copyright © 2022 Anil, Peeri and Koltai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Anil, Seegehalli M. Peeri, Hadar Koltai, Hinanit Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action |
title | Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action |
title_full | Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action |
title_fullStr | Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action |
title_full_unstemmed | Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action |
title_short | Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action |
title_sort | medical cannabis activity against inflammation: active compounds and modes of action |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124761/ https://www.ncbi.nlm.nih.gov/pubmed/35614947 http://dx.doi.org/10.3389/fphar.2022.908198 |
work_keys_str_mv | AT anilseegehallim medicalcannabisactivityagainstinflammationactivecompoundsandmodesofaction AT peerihadar medicalcannabisactivityagainstinflammationactivecompoundsandmodesofaction AT koltaihinanit medicalcannabisactivityagainstinflammationactivecompoundsandmodesofaction |