Cargando…

From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?

Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leads to the dysregulation of the immune system, exacerbates inflammatory responses, and even causes multiple organ dysfunction syndrome in patients with severe disease. Sarcoidosis...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Min, Tian, Chang, Cong, Shan, Di, Xin, Wang, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124764/
https://www.ncbi.nlm.nih.gov/pubmed/35615369
http://dx.doi.org/10.3389/fimmu.2022.877303
_version_ 1784711794855510016
author Zhao, Min
Tian, Chang
Cong, Shan
Di, Xin
Wang, Ke
author_facet Zhao, Min
Tian, Chang
Cong, Shan
Di, Xin
Wang, Ke
author_sort Zhao, Min
collection PubMed
description Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leads to the dysregulation of the immune system, exacerbates inflammatory responses, and even causes multiple organ dysfunction syndrome in patients with severe disease. Sarcoidosis is an idiopathic granulomatous multisystem disease characterized by dense epithelioid non-necrotizing lesions with varying degrees of lymphocytic inflammation. These two diseases have similar clinical manifestations and may also influence each other and affect their clinical courses. In this study, we analyzed some possible connections between sarcoidosis and COVID-19, including the role of the renin–angiotensin system in the respiratory system, immune response, and cell death pathways, to understand the underlying mechanisms of SARS-CoV-2 infection, predisposing patients to severe forms of COVID-19. This review will provide a new prospect for the treatment of COVID-19 and an opportunity to explore the pathogenesis and development of sarcoidosis.
format Online
Article
Text
id pubmed-9124764
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91247642022-05-24 From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases? Zhao, Min Tian, Chang Cong, Shan Di, Xin Wang, Ke Front Immunol Immunology Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leads to the dysregulation of the immune system, exacerbates inflammatory responses, and even causes multiple organ dysfunction syndrome in patients with severe disease. Sarcoidosis is an idiopathic granulomatous multisystem disease characterized by dense epithelioid non-necrotizing lesions with varying degrees of lymphocytic inflammation. These two diseases have similar clinical manifestations and may also influence each other and affect their clinical courses. In this study, we analyzed some possible connections between sarcoidosis and COVID-19, including the role of the renin–angiotensin system in the respiratory system, immune response, and cell death pathways, to understand the underlying mechanisms of SARS-CoV-2 infection, predisposing patients to severe forms of COVID-19. This review will provide a new prospect for the treatment of COVID-19 and an opportunity to explore the pathogenesis and development of sarcoidosis. Frontiers Media S.A. 2022-05-09 /pmc/articles/PMC9124764/ /pubmed/35615369 http://dx.doi.org/10.3389/fimmu.2022.877303 Text en Copyright © 2022 Zhao, Tian, Cong, Di and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhao, Min
Tian, Chang
Cong, Shan
Di, Xin
Wang, Ke
From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?
title From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?
title_full From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?
title_fullStr From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?
title_full_unstemmed From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?
title_short From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?
title_sort from covid-19 to sarcoidosis: how similar are these two diseases?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124764/
https://www.ncbi.nlm.nih.gov/pubmed/35615369
http://dx.doi.org/10.3389/fimmu.2022.877303
work_keys_str_mv AT zhaomin fromcovid19tosarcoidosishowsimilararethesetwodiseases
AT tianchang fromcovid19tosarcoidosishowsimilararethesetwodiseases
AT congshan fromcovid19tosarcoidosishowsimilararethesetwodiseases
AT dixin fromcovid19tosarcoidosishowsimilararethesetwodiseases
AT wangke fromcovid19tosarcoidosishowsimilararethesetwodiseases