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From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leads to the dysregulation of the immune system, exacerbates inflammatory responses, and even causes multiple organ dysfunction syndrome in patients with severe disease. Sarcoidosis...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124764/ https://www.ncbi.nlm.nih.gov/pubmed/35615369 http://dx.doi.org/10.3389/fimmu.2022.877303 |
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author | Zhao, Min Tian, Chang Cong, Shan Di, Xin Wang, Ke |
author_facet | Zhao, Min Tian, Chang Cong, Shan Di, Xin Wang, Ke |
author_sort | Zhao, Min |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leads to the dysregulation of the immune system, exacerbates inflammatory responses, and even causes multiple organ dysfunction syndrome in patients with severe disease. Sarcoidosis is an idiopathic granulomatous multisystem disease characterized by dense epithelioid non-necrotizing lesions with varying degrees of lymphocytic inflammation. These two diseases have similar clinical manifestations and may also influence each other and affect their clinical courses. In this study, we analyzed some possible connections between sarcoidosis and COVID-19, including the role of the renin–angiotensin system in the respiratory system, immune response, and cell death pathways, to understand the underlying mechanisms of SARS-CoV-2 infection, predisposing patients to severe forms of COVID-19. This review will provide a new prospect for the treatment of COVID-19 and an opportunity to explore the pathogenesis and development of sarcoidosis. |
format | Online Article Text |
id | pubmed-9124764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91247642022-05-24 From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases? Zhao, Min Tian, Chang Cong, Shan Di, Xin Wang, Ke Front Immunol Immunology Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leads to the dysregulation of the immune system, exacerbates inflammatory responses, and even causes multiple organ dysfunction syndrome in patients with severe disease. Sarcoidosis is an idiopathic granulomatous multisystem disease characterized by dense epithelioid non-necrotizing lesions with varying degrees of lymphocytic inflammation. These two diseases have similar clinical manifestations and may also influence each other and affect their clinical courses. In this study, we analyzed some possible connections between sarcoidosis and COVID-19, including the role of the renin–angiotensin system in the respiratory system, immune response, and cell death pathways, to understand the underlying mechanisms of SARS-CoV-2 infection, predisposing patients to severe forms of COVID-19. This review will provide a new prospect for the treatment of COVID-19 and an opportunity to explore the pathogenesis and development of sarcoidosis. Frontiers Media S.A. 2022-05-09 /pmc/articles/PMC9124764/ /pubmed/35615369 http://dx.doi.org/10.3389/fimmu.2022.877303 Text en Copyright © 2022 Zhao, Tian, Cong, Di and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhao, Min Tian, Chang Cong, Shan Di, Xin Wang, Ke From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases? |
title | From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases? |
title_full | From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases? |
title_fullStr | From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases? |
title_full_unstemmed | From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases? |
title_short | From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases? |
title_sort | from covid-19 to sarcoidosis: how similar are these two diseases? |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124764/ https://www.ncbi.nlm.nih.gov/pubmed/35615369 http://dx.doi.org/10.3389/fimmu.2022.877303 |
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