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Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases
Sirtuins are protein factors that can delay aging and alleviate age-related diseases through multiple molecular pathways, mainly by promoting DNA damage repair, delaying telomere shortening, and mediating the longevity effect of caloric restriction. In the last decade, sirtuins have also been sugges...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124796/ https://www.ncbi.nlm.nih.gov/pubmed/35615591 http://dx.doi.org/10.3389/fnagi.2022.845330 |
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author | Wan, Wei Hua, Fuzhou Fang, Pu Li, Chang Deng, Fumou Chen, Shoulin Ying, Jun Wang, Xifeng |
author_facet | Wan, Wei Hua, Fuzhou Fang, Pu Li, Chang Deng, Fumou Chen, Shoulin Ying, Jun Wang, Xifeng |
author_sort | Wan, Wei |
collection | PubMed |
description | Sirtuins are protein factors that can delay aging and alleviate age-related diseases through multiple molecular pathways, mainly by promoting DNA damage repair, delaying telomere shortening, and mediating the longevity effect of caloric restriction. In the last decade, sirtuins have also been suggested to exert mitochondrial quality control by mediating mitophagy, which targets damaged mitochondria and delivers them to lysosomes for degradation. This is especially significant for age-related diseases because dysfunctional mitochondria accumulate in aging organisms. Accordingly, it has been suggested that sirtuins and mitophagy have many common and interactive aspects in the aging process. This article reviews the mechanisms and pathways of sirtuin family-mediated mitophagy and further discusses its role in aging and age-related diseases. |
format | Online Article Text |
id | pubmed-9124796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91247962022-05-24 Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases Wan, Wei Hua, Fuzhou Fang, Pu Li, Chang Deng, Fumou Chen, Shoulin Ying, Jun Wang, Xifeng Front Aging Neurosci Aging Neuroscience Sirtuins are protein factors that can delay aging and alleviate age-related diseases through multiple molecular pathways, mainly by promoting DNA damage repair, delaying telomere shortening, and mediating the longevity effect of caloric restriction. In the last decade, sirtuins have also been suggested to exert mitochondrial quality control by mediating mitophagy, which targets damaged mitochondria and delivers them to lysosomes for degradation. This is especially significant for age-related diseases because dysfunctional mitochondria accumulate in aging organisms. Accordingly, it has been suggested that sirtuins and mitophagy have many common and interactive aspects in the aging process. This article reviews the mechanisms and pathways of sirtuin family-mediated mitophagy and further discusses its role in aging and age-related diseases. Frontiers Media S.A. 2022-05-09 /pmc/articles/PMC9124796/ /pubmed/35615591 http://dx.doi.org/10.3389/fnagi.2022.845330 Text en Copyright © 2022 Wan, Hua, Fang, Li, Deng, Chen, Ying and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Wan, Wei Hua, Fuzhou Fang, Pu Li, Chang Deng, Fumou Chen, Shoulin Ying, Jun Wang, Xifeng Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases |
title | Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases |
title_full | Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases |
title_fullStr | Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases |
title_full_unstemmed | Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases |
title_short | Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases |
title_sort | regulation of mitophagy by sirtuin family proteins: a vital role in aging and age-related diseases |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124796/ https://www.ncbi.nlm.nih.gov/pubmed/35615591 http://dx.doi.org/10.3389/fnagi.2022.845330 |
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