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In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions

Fenfluramine (FFA) has potent antiseizure activity in severe, pharmacoresistant childhood‐onset developmental and epileptic encephalopathies (e.g., Dravet syndrome). To assess risk of drug interaction affecting pharmacokinetics of FFA and its major metabolite, norfenfluramine (nFFA), we conducted in...

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Detalles Bibliográficos
Autores principales:	Martin, Parthena, Czerwiński, Maciej, Limaye, Pallavi B., Muranjan, Seema, Ogilvie, Brian W., Smith, Steven, Boyd, Brooks
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Invited Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124820/ https://www.ncbi.nlm.nih.gov/pubmed/35599345 http://dx.doi.org/10.1002/prp2.958

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