Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models

Immunotherapy with T-cells expressing bispecific T-cell engagers (ENG T-cells) is a promising approach to improve the outcomes for patients with recurrent/refractory acute myeloid leukemia (AML). However, similar to T-cells expressing chimeric antigen receptors (CARs), their antitumor activity is li...

Descripción completa

Detalles Bibliográficos
Autores principales: Mu-Mosley, Hong, Ostermann, Lauren, Muftuoglu, Muharrem, Vaidya, Abishek, Bonifant, Challice L., Velasquez, Mireya Paulina, Gottschalk, Stephen, Andreeff, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124830/
https://www.ncbi.nlm.nih.gov/pubmed/35615350
http://dx.doi.org/10.3389/fimmu.2022.880108

Ejemplares similares

Ejemplares similares