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Myocilin Gene Mutation Induced Autophagy Activation Causes Dysfunction of Trabecular Meshwork Cells

Trabecular meshwork dysfunction is the main cause of primary open angle glaucoma (POAG) associated with elevated intraocular pressure (IOP). Mutant myocilin causes glaucoma mainly via elevating IOP. Previously we have found that accumulated Asn 450 Tyr (N450Y) mutant myocilin impairs human trabecula...

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Detalles Bibliográficos
Autores principales:	Yan, Xuejing, Wu, Shen, Liu, Qian, Cheng, Ying, Zhang, Jingxue, Wang, Ningli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124892/ https://www.ncbi.nlm.nih.gov/pubmed/35615698 http://dx.doi.org/10.3389/fcell.2022.900777

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