EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance

Ephrin-A1 is a protein that in humans is encoded by the EFNA1 gene. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases which play an indispensable role in normal growth and development or in the pathophysiology of various tumors. The role of EFN...

Descripción completa

Detalles Bibliográficos
Autores principales: Chu, Ling-Yu, Huang, Bin-Liang, Huang, Xu-Chun, Peng, Yu-Hui, Xie, Jian-Jun, Xu, Yi-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124989/
https://www.ncbi.nlm.nih.gov/pubmed/35646281
http://dx.doi.org/10.4251/wjgo.v14.i5.973
Descripción
Sumario:Ephrin-A1 is a protein that in humans is encoded by the EFNA1 gene. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases which play an indispensable role in normal growth and development or in the pathophysiology of various tumors. The role of EFNA1 in tumorigenesis and development is complex and depends on the cell type and microenvironment which in turn affect the expression of EFNA1. This article reviews the expression, prognostic value, regulation and clinical significance of EFNA1 in gastrointestinal tumors.

Ejemplares similares