EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance

Ephrin-A1 is a protein that in humans is encoded by the EFNA1 gene. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases which play an indispensable role in normal growth and development or in the pathophysiology of various tumors. The role of EFN...

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Autores principales: Chu, Ling-Yu, Huang, Bin-Liang, Huang, Xu-Chun, Peng, Yu-Hui, Xie, Jian-Jun, Xu, Yi-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124989/
https://www.ncbi.nlm.nih.gov/pubmed/35646281
http://dx.doi.org/10.4251/wjgo.v14.i5.973
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author Chu, Ling-Yu
Huang, Bin-Liang
Huang, Xu-Chun
Peng, Yu-Hui
Xie, Jian-Jun
Xu, Yi-Wei
author_facet Chu, Ling-Yu
Huang, Bin-Liang
Huang, Xu-Chun
Peng, Yu-Hui
Xie, Jian-Jun
Xu, Yi-Wei
author_sort Chu, Ling-Yu
collection PubMed
description Ephrin-A1 is a protein that in humans is encoded by the EFNA1 gene. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases which play an indispensable role in normal growth and development or in the pathophysiology of various tumors. The role of EFNA1 in tumorigenesis and development is complex and depends on the cell type and microenvironment which in turn affect the expression of EFNA1. This article reviews the expression, prognostic value, regulation and clinical significance of EFNA1 in gastrointestinal tumors.
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spelling pubmed-91249892022-05-27 EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance Chu, Ling-Yu Huang, Bin-Liang Huang, Xu-Chun Peng, Yu-Hui Xie, Jian-Jun Xu, Yi-Wei World J Gastrointest Oncol Review Ephrin-A1 is a protein that in humans is encoded by the EFNA1 gene. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases which play an indispensable role in normal growth and development or in the pathophysiology of various tumors. The role of EFNA1 in tumorigenesis and development is complex and depends on the cell type and microenvironment which in turn affect the expression of EFNA1. This article reviews the expression, prognostic value, regulation and clinical significance of EFNA1 in gastrointestinal tumors. Baishideng Publishing Group Inc 2022-05-15 2022-05-15 /pmc/articles/PMC9124989/ /pubmed/35646281 http://dx.doi.org/10.4251/wjgo.v14.i5.973 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Review
Chu, Ling-Yu
Huang, Bin-Liang
Huang, Xu-Chun
Peng, Yu-Hui
Xie, Jian-Jun
Xu, Yi-Wei
EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance
title EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance
title_full EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance
title_fullStr EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance
title_full_unstemmed EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance
title_short EFNA1 in gastrointestinal cancer: Expression, regulation and clinical significance
title_sort efna1 in gastrointestinal cancer: expression, regulation and clinical significance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124989/
https://www.ncbi.nlm.nih.gov/pubmed/35646281
http://dx.doi.org/10.4251/wjgo.v14.i5.973
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AT xiejianjun efna1ingastrointestinalcancerexpressionregulationandclinicalsignificance
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