Cargando…

Effects of 3-Methyladenine on Microglia Autophagy and Neuronal Apoptosis After Radiation-Induced Brain Injury

OBJECTIVE: To determine the effect of the autophagy inhibitor, 3-methyladenine (3-MA), on cognitive function changes, microglia activity, neuronal apoptosis, and inflammation in rats following radiation-induced brain injury. METHODS: The following groups were established: control, model, and 3-MA. A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Huichao, Cui, Yahuan, Liu, Jing, Liu, Meiyi, Zhou, Wei, Yan, Zhenyu, Zhang, Haixia, Wang, Yingman, Wang, Xueming, Liu, Xiaomin, Chen, Naiyao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125074/ https://www.ncbi.nlm.nih.gov/pubmed/35615570 http://dx.doi.org/10.1177/15593258221100593

Ejemplares similares

Mesenchymal Stem Cell-Conditioned Medium Protects Hippocampal Neurons From Radiation Damage by Suppressing Oxidative Stress and Apoptosis
por: Huang, Yue, et al.
Publicado: (2021)

3-Methyladenine-enhanced susceptibility to sorafenib in hepatocellular carcinoma cells by inhibiting autophagy
por: Zhao, Fangfang, et al.
Publicado: (2021)

Autophagy Inhibition via Hydroxychloroquine or 3-Methyladenine Enhances Chemotherapy-Induced Apoptosis in Neuro-Blastoma and Glioblastoma
por: Wear, Darcy, et al.
Publicado: (2023)

Role of autophagy in the progression of osteoarthritis: The autophagy inhibitor, 3-methyladenine, aggravates the severity of experimental osteoarthritis
por: Cheng, Ni-Tao, et al.
Publicado: (2017)

The inflammatory injury in the striatal microglia-dopaminergic-neuron crosstalk involved in Tourette syndrome development
por: Wang, Xueming, et al.
Publicado: (2023)

A model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus
por: Zhu, Xiaofeng, et al.
Publicado: (2012)

DNA N(6)-methyladenine modification in hypertension
por: Guo, Ye, et al.
Publicado: (2020)

Inhibition of autophagy using 3-methyladenine increases cisplatin-induced apoptosis by increasing endoplasmic reticulum stress in U251 human glioma cells
por: ZHANG, RUIJIAN, et al.
Publicado: (2015)

Effects of autophagy inhibitor 3-Methyladenine on ischemic stroke: A protocol for systematic review and meta-analysis
por: Zhang, Ao, et al.
Publicado: (2021)

Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions
por: Zhang, Peng, et al.
Publicado: (2020)

N(6)-methyladenine is incorporated into mammalian genome by DNA polymerase
por: Liu, Xiaoling, et al.
Publicado: (2020)

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
por: Choi, Insup, et al.
Publicado: (2020)

N6‐methyladenine‐related genes affect biological behavior and the prognosis of glioma
por: Qu, Shanqiang, et al.
Publicado: (2020)

Inhibition of autophagy with 3-methyladenine is protective in a lethal model of murine endotoxemia and polymicrobial sepsis
por: Li, Qirui, et al.
Publicado: (2018)

Inhibition of autophagy by 3-methyladenine promotes migration and invasion of colon cancer cells through epithelial mesenchymal transformation
por: Zhang, Xiaoyang, et al.
Publicado: (2022)

Bone marrow mesenchymal stem cells from leukemia patients inhibit growth and apoptosis in serum-deprived K562 cells
por: Wei, Zhaohui, et al.
Publicado: (2009)

N6-methyladenine modification in noncoding RNAs and its function in cancer
por: Yang, Xinyu, et al.
Publicado: (2020)

Cell Death Triggered by the Autophagy Inhibitory Drug 3-Methyladenine in Growing Conditions Proceeds With DNA Damage
por: Chicote, Javier, et al.
Publicado: (2020)

DNA N6-Methyladenine Modification in Eukaryotic Genome
por: Li, Hao, et al.
Publicado: (2022)

No evidence for DNA N(6)-methyladenine in mammals
por: Douvlataniotis, Karolos, et al.
Publicado: (2020)

Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration
por: Alirezaei, Mehrdad, et al.
Publicado: (2008)

Activated microglia contribute to neuronal apoptosis in Toxoplasmic encephalitis
por: Zhang, Yi-hua, et al.
Publicado: (2014)

N(6)-Methyladenine in Eukaryotic DNA: Tissue Distribution, Early Embryo Development, and Neuronal Toxicity
por: Fernandes, Sara B., et al.
Publicado: (2021)

Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE(−/−) mice by modulating autophagy, foam cell formation and immune-negative molecules
por: Dai, Shen, et al.
Publicado: (2016)

3-Methyladenine ameliorates liver fibrosis through autophagy regulated by the NF-κB signaling pathways on hepatic stellate cell
por: Wang, Bingying, et al.
Publicado: (2017)

Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression
por: Wang, Haixia, et al.
Publicado: (2022)

N(6)-methyladenine in DNA antagonizes SATB1 in early development
por: Li, Zheng, et al.
Publicado: (2020)

Single-Nucleotide Resolution Mapping of N(6)-Methyladenine in Genomic DNA
por: Ma, Cheng-Jie, et al.
Publicado: (2023)

Effect of N3-Methyladenine and an Isosteric Stable Analogue on DNA Polymerization
por: Settles, Samuel, et al.
Publicado: (2010)

The inhibitory effect of minocycline on radiation-induced neuronal apoptosis via AMPKα1 signaling-mediated autophagy
por: Zhang, Liyuan, et al.
Publicado: (2017)

Identification of DNA N(6)-methyladenine sites by integration of sequence features
por: Wang, Hao-Tian, et al.
Publicado: (2020)

RNA N(6)-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness
por: Chen, Huarong, et al.
Publicado: (2022)

M1 Microglia Induced Neuronal Injury on Ischemic Stroke via Mitochondrial Crosstalk between Microglia and Neurons
por: Liu, Wei, et al.
Publicado: (2022)

N6-methyladenine-modified DNA was decreased in Alzheimer’s disease patients
por: Lv, Shuang, et al.
Publicado: (2022)

N6-Methyladenine DNA modification in Xanthomonas oryzae pv. oryzicola genome
por: Xiao, Chuan-Le, et al.
Publicado: (2018)

Emerging Roles of Microglia in Neuro-vascular Unit: Implications of Microglia-Neurons Interactions
por: Ding, Zhe, et al.
Publicado: (2021)

N(6)-methyladenine: a potential epigenetic mark in eukaryotes
por: Huang, Shoujun, et al.
Publicado: (2015)

Molecular characterization of Plasmodium falciparum DNA-3-methyladenine glycosylase
por: Pinthong, Nattapon, et al.
Publicado: (2020)

Role of Interleukin33 in Rejuvenation of Aged Neurons and Age-Related Dementias
por: Lou, Yahuan
Publicado: (2021)

The dynamics of N(6)-methyladenine RNA modification in interactions between rice and plant viruses
por: Zhang, Kun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3ms6b31fhdcte6jridddg56iok