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Understanding brain states across spacetime informed by whole-brain modelling

In order to survive in a complex environment, the human brain relies on the ability to flexibly adapt ongoing behaviour according to intrinsic and extrinsic signals. This capability has been linked to specific whole-brain activity patterns whose relative stability (order) allows for consistent funct...

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Autores principales: Vohryzek, Jakub, Cabral, Joana, Vuust, Peter, Deco, Gustavo, Kringelbach, Morten L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125224/
https://www.ncbi.nlm.nih.gov/pubmed/35599554
http://dx.doi.org/10.1098/rsta.2021.0247
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author Vohryzek, Jakub
Cabral, Joana
Vuust, Peter
Deco, Gustavo
Kringelbach, Morten L.
author_facet Vohryzek, Jakub
Cabral, Joana
Vuust, Peter
Deco, Gustavo
Kringelbach, Morten L.
author_sort Vohryzek, Jakub
collection PubMed
description In order to survive in a complex environment, the human brain relies on the ability to flexibly adapt ongoing behaviour according to intrinsic and extrinsic signals. This capability has been linked to specific whole-brain activity patterns whose relative stability (order) allows for consistent functioning, supported by sufficient intrinsic instability needed for optimal adaptability. The emergent, spontaneous balance between order and disorder in brain activity over spacetime underpins distinct brain states. For example, depression is characterized by excessively rigid, highly ordered states, while psychedelics can bring about more disordered, sometimes overly flexible states. Recent developments in systems, computational and theoretical neuroscience have started to make inroads into the characterization of such complex dynamics over space and time. Here, we review recent insights drawn from neuroimaging and whole-brain modelling motivating using mechanistic principles from dynamical system theory to study and characterize brain states. We show how different healthy and altered brain states are associated to characteristic spacetime dynamics which in turn may offer insights that in time can inspire new treatments for rebalancing brain states in disease. This article is part of the theme issue ‘Emergent phenomena in complex physical and socio-technical systems: from cells to societies’.
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spelling pubmed-91252242022-05-27 Understanding brain states across spacetime informed by whole-brain modelling Vohryzek, Jakub Cabral, Joana Vuust, Peter Deco, Gustavo Kringelbach, Morten L. Philos Trans A Math Phys Eng Sci Articles In order to survive in a complex environment, the human brain relies on the ability to flexibly adapt ongoing behaviour according to intrinsic and extrinsic signals. This capability has been linked to specific whole-brain activity patterns whose relative stability (order) allows for consistent functioning, supported by sufficient intrinsic instability needed for optimal adaptability. The emergent, spontaneous balance between order and disorder in brain activity over spacetime underpins distinct brain states. For example, depression is characterized by excessively rigid, highly ordered states, while psychedelics can bring about more disordered, sometimes overly flexible states. Recent developments in systems, computational and theoretical neuroscience have started to make inroads into the characterization of such complex dynamics over space and time. Here, we review recent insights drawn from neuroimaging and whole-brain modelling motivating using mechanistic principles from dynamical system theory to study and characterize brain states. We show how different healthy and altered brain states are associated to characteristic spacetime dynamics which in turn may offer insights that in time can inspire new treatments for rebalancing brain states in disease. This article is part of the theme issue ‘Emergent phenomena in complex physical and socio-technical systems: from cells to societies’. The Royal Society 2022-07-11 2022-05-23 /pmc/articles/PMC9125224/ /pubmed/35599554 http://dx.doi.org/10.1098/rsta.2021.0247 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Articles
Vohryzek, Jakub
Cabral, Joana
Vuust, Peter
Deco, Gustavo
Kringelbach, Morten L.
Understanding brain states across spacetime informed by whole-brain modelling
title Understanding brain states across spacetime informed by whole-brain modelling
title_full Understanding brain states across spacetime informed by whole-brain modelling
title_fullStr Understanding brain states across spacetime informed by whole-brain modelling
title_full_unstemmed Understanding brain states across spacetime informed by whole-brain modelling
title_short Understanding brain states across spacetime informed by whole-brain modelling
title_sort understanding brain states across spacetime informed by whole-brain modelling
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125224/
https://www.ncbi.nlm.nih.gov/pubmed/35599554
http://dx.doi.org/10.1098/rsta.2021.0247
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