Recent Progress on Feasible Strategies for Arbutin Production

Arbutin is a hydroquinone glucoside and a natural product present in various plants. Arbutin potently inhibits melanin formation. This property has been exploited in whitening cosmetics and pharmaceuticals. Arbutin production relies mainly on chemical synthesis. The multi-step and complicated proces...

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Autores principales: Xu, Ke-Xin, Xue, Meng-Ge, Li, Zhimin, Ye, Bang-Ce, Zhang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125391/
https://www.ncbi.nlm.nih.gov/pubmed/35615473
http://dx.doi.org/10.3389/fbioe.2022.914280
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author Xu, Ke-Xin
Xue, Meng-Ge
Li, Zhimin
Ye, Bang-Ce
Zhang, Bin
author_facet Xu, Ke-Xin
Xue, Meng-Ge
Li, Zhimin
Ye, Bang-Ce
Zhang, Bin
author_sort Xu, Ke-Xin
collection PubMed
description Arbutin is a hydroquinone glucoside and a natural product present in various plants. Arbutin potently inhibits melanin formation. This property has been exploited in whitening cosmetics and pharmaceuticals. Arbutin production relies mainly on chemical synthesis. The multi-step and complicated process can compromise product purity. With the increasing awareness of sustainable development, the current research direction prioritizes environment-friendly, biobased arbutin production. In this review, current strategies for arbutin production are critically reviewed, with a focus on plant extraction, chemical synthesis, biotransformation, and microbial fermentation. Furthermore, the bottlenecks and perspectives for future direction on arbutin biosynthesis are discussed.
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spelling pubmed-91253912022-05-24 Recent Progress on Feasible Strategies for Arbutin Production Xu, Ke-Xin Xue, Meng-Ge Li, Zhimin Ye, Bang-Ce Zhang, Bin Front Bioeng Biotechnol Bioengineering and Biotechnology Arbutin is a hydroquinone glucoside and a natural product present in various plants. Arbutin potently inhibits melanin formation. This property has been exploited in whitening cosmetics and pharmaceuticals. Arbutin production relies mainly on chemical synthesis. The multi-step and complicated process can compromise product purity. With the increasing awareness of sustainable development, the current research direction prioritizes environment-friendly, biobased arbutin production. In this review, current strategies for arbutin production are critically reviewed, with a focus on plant extraction, chemical synthesis, biotransformation, and microbial fermentation. Furthermore, the bottlenecks and perspectives for future direction on arbutin biosynthesis are discussed. Frontiers Media S.A. 2022-05-09 /pmc/articles/PMC9125391/ /pubmed/35615473 http://dx.doi.org/10.3389/fbioe.2022.914280 Text en Copyright © 2022 Xu, Xue, Li, Ye and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Xu, Ke-Xin
Xue, Meng-Ge
Li, Zhimin
Ye, Bang-Ce
Zhang, Bin
Recent Progress on Feasible Strategies for Arbutin Production
title Recent Progress on Feasible Strategies for Arbutin Production
title_full Recent Progress on Feasible Strategies for Arbutin Production
title_fullStr Recent Progress on Feasible Strategies for Arbutin Production
title_full_unstemmed Recent Progress on Feasible Strategies for Arbutin Production
title_short Recent Progress on Feasible Strategies for Arbutin Production
title_sort recent progress on feasible strategies for arbutin production
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125391/
https://www.ncbi.nlm.nih.gov/pubmed/35615473
http://dx.doi.org/10.3389/fbioe.2022.914280
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