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Primary eosinophilic gastrointestinal disorders and allergy: Clinical and therapeutic implications
Primary eosinophilic gastrointestinal disorders (EGID) are increasingly prevalent, immune‐mediated, chronic conditions which primarily affect pediatric and young adult patients, leading to substantial disease burden, and poor quality of life. EGID may either involve single portions of the gastrointe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125508/ https://www.ncbi.nlm.nih.gov/pubmed/35620572 http://dx.doi.org/10.1002/clt2.12146 |
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author | Rossi, Carlo Maria Lenti, Marco Vincenzo Merli, Stefania Licari, Amelia Votto, Martina Marseglia, Gian Luigi Di Sabatino, Antonio |
author_facet | Rossi, Carlo Maria Lenti, Marco Vincenzo Merli, Stefania Licari, Amelia Votto, Martina Marseglia, Gian Luigi Di Sabatino, Antonio |
author_sort | Rossi, Carlo Maria |
collection | PubMed |
description | Primary eosinophilic gastrointestinal disorders (EGID) are increasingly prevalent, immune‐mediated, chronic conditions which primarily affect pediatric and young adult patients, leading to substantial disease burden, and poor quality of life. EGID may either involve single portions of the gastrointestinal tract (i.e., esophagus, stomach, small bowel, and colon) or a combination. Their strong association with allergic disorders has been recently recognized, and although their shared pathophysiological basis remains partly elusive, this feature greatly impacts the diagnostic and treatment work‐up. We herein critically discuss the current knowledge on the association of EGID and allergic disorders, including atopic dermatitis, allergic rhinitis, allergic asthma, and food or drug allergy. In particular, we reviewed the literature focusing on their epidemiology, pathophysiological basis and mechanisms, and diagnostic strategies. Finally, we discuss the currently ongoing clinical trials targeting EGID and allergic diseases, including, among others the monoclonal antibodies dupilumab, mepolizumab, benralizumab, and lirentelimab. |
format | Online Article Text |
id | pubmed-9125508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91255082022-05-25 Primary eosinophilic gastrointestinal disorders and allergy: Clinical and therapeutic implications Rossi, Carlo Maria Lenti, Marco Vincenzo Merli, Stefania Licari, Amelia Votto, Martina Marseglia, Gian Luigi Di Sabatino, Antonio Clin Transl Allergy Review Article Primary eosinophilic gastrointestinal disorders (EGID) are increasingly prevalent, immune‐mediated, chronic conditions which primarily affect pediatric and young adult patients, leading to substantial disease burden, and poor quality of life. EGID may either involve single portions of the gastrointestinal tract (i.e., esophagus, stomach, small bowel, and colon) or a combination. Their strong association with allergic disorders has been recently recognized, and although their shared pathophysiological basis remains partly elusive, this feature greatly impacts the diagnostic and treatment work‐up. We herein critically discuss the current knowledge on the association of EGID and allergic disorders, including atopic dermatitis, allergic rhinitis, allergic asthma, and food or drug allergy. In particular, we reviewed the literature focusing on their epidemiology, pathophysiological basis and mechanisms, and diagnostic strategies. Finally, we discuss the currently ongoing clinical trials targeting EGID and allergic diseases, including, among others the monoclonal antibodies dupilumab, mepolizumab, benralizumab, and lirentelimab. John Wiley and Sons Inc. 2022-05-23 /pmc/articles/PMC9125508/ /pubmed/35620572 http://dx.doi.org/10.1002/clt2.12146 Text en © 2022 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rossi, Carlo Maria Lenti, Marco Vincenzo Merli, Stefania Licari, Amelia Votto, Martina Marseglia, Gian Luigi Di Sabatino, Antonio Primary eosinophilic gastrointestinal disorders and allergy: Clinical and therapeutic implications |
title | Primary eosinophilic gastrointestinal disorders and allergy: Clinical and therapeutic implications |
title_full | Primary eosinophilic gastrointestinal disorders and allergy: Clinical and therapeutic implications |
title_fullStr | Primary eosinophilic gastrointestinal disorders and allergy: Clinical and therapeutic implications |
title_full_unstemmed | Primary eosinophilic gastrointestinal disorders and allergy: Clinical and therapeutic implications |
title_short | Primary eosinophilic gastrointestinal disorders and allergy: Clinical and therapeutic implications |
title_sort | primary eosinophilic gastrointestinal disorders and allergy: clinical and therapeutic implications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125508/ https://www.ncbi.nlm.nih.gov/pubmed/35620572 http://dx.doi.org/10.1002/clt2.12146 |
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