Cargando…

Mathematical Model of HIV/AIDS Considering Sexual Preferences Under Antiretroviral Therapy, a Case Study in San Juan de Pasto, Colombia

While several studies on human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) in the homosexual and heterosexual population have demonstrated substantial advantages in controlling HIV transmission in these groups, the overall 2benefits of the models with a bisexual population...

Descripción completa

Detalles Bibliográficos
Autores principales: Espitia, Cristian C., Botina, Miguel A., Solarte, Marco A., Hernandez, Ivan, Riascos, Ricardo A., Meyer, João F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125573/
https://www.ncbi.nlm.nih.gov/pubmed/35544039
http://dx.doi.org/10.1089/cmb.2021.0323
_version_ 1784711964792979456
author Espitia, Cristian C.
Botina, Miguel A.
Solarte, Marco A.
Hernandez, Ivan
Riascos, Ricardo A.
Meyer, João F.
author_facet Espitia, Cristian C.
Botina, Miguel A.
Solarte, Marco A.
Hernandez, Ivan
Riascos, Ricardo A.
Meyer, João F.
author_sort Espitia, Cristian C.
collection PubMed
description While several studies on human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) in the homosexual and heterosexual population have demonstrated substantial advantages in controlling HIV transmission in these groups, the overall 2benefits of the models with a bisexual population and initiation of antiretroviral therapy have not had enough attention in dynamic modeling. Thus, we used a mathematical model based on studying the impacts of bisexual behavior in a global community developed in the PhD thesis work of Espitia (2021). The model is governed by a nonlinear ordinary differential equation system, the parameters of which are calibrated with data from the cumulative cases of HIV infection and AIDS reported in San Juan de Pasto in 2019. Our model estimations show which parameters are the most influential and how to modulate them to decrease the HIV infection.
format Online
Article
Text
id pubmed-9125573
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Mary Ann Liebert, Inc., publishers
record_format MEDLINE/PubMed
spelling pubmed-91255732022-05-23 Mathematical Model of HIV/AIDS Considering Sexual Preferences Under Antiretroviral Therapy, a Case Study in San Juan de Pasto, Colombia Espitia, Cristian C. Botina, Miguel A. Solarte, Marco A. Hernandez, Ivan Riascos, Ricardo A. Meyer, João F. J Comput Biol Research Articles While several studies on human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) in the homosexual and heterosexual population have demonstrated substantial advantages in controlling HIV transmission in these groups, the overall 2benefits of the models with a bisexual population and initiation of antiretroviral therapy have not had enough attention in dynamic modeling. Thus, we used a mathematical model based on studying the impacts of bisexual behavior in a global community developed in the PhD thesis work of Espitia (2021). The model is governed by a nonlinear ordinary differential equation system, the parameters of which are calibrated with data from the cumulative cases of HIV infection and AIDS reported in San Juan de Pasto in 2019. Our model estimations show which parameters are the most influential and how to modulate them to decrease the HIV infection. Mary Ann Liebert, Inc., publishers 2022-05-01 2022-05-10 /pmc/articles/PMC9125573/ /pubmed/35544039 http://dx.doi.org/10.1089/cmb.2021.0323 Text en © Cristian C. Espitia, et al., 2022. Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Articles
Espitia, Cristian C.
Botina, Miguel A.
Solarte, Marco A.
Hernandez, Ivan
Riascos, Ricardo A.
Meyer, João F.
Mathematical Model of HIV/AIDS Considering Sexual Preferences Under Antiretroviral Therapy, a Case Study in San Juan de Pasto, Colombia
title Mathematical Model of HIV/AIDS Considering Sexual Preferences Under Antiretroviral Therapy, a Case Study in San Juan de Pasto, Colombia
title_full Mathematical Model of HIV/AIDS Considering Sexual Preferences Under Antiretroviral Therapy, a Case Study in San Juan de Pasto, Colombia
title_fullStr Mathematical Model of HIV/AIDS Considering Sexual Preferences Under Antiretroviral Therapy, a Case Study in San Juan de Pasto, Colombia
title_full_unstemmed Mathematical Model of HIV/AIDS Considering Sexual Preferences Under Antiretroviral Therapy, a Case Study in San Juan de Pasto, Colombia
title_short Mathematical Model of HIV/AIDS Considering Sexual Preferences Under Antiretroviral Therapy, a Case Study in San Juan de Pasto, Colombia
title_sort mathematical model of hiv/aids considering sexual preferences under antiretroviral therapy, a case study in san juan de pasto, colombia
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125573/
https://www.ncbi.nlm.nih.gov/pubmed/35544039
http://dx.doi.org/10.1089/cmb.2021.0323
work_keys_str_mv AT espitiacristianc mathematicalmodelofhivaidsconsideringsexualpreferencesunderantiretroviraltherapyacasestudyinsanjuandepastocolombia
AT botinamiguela mathematicalmodelofhivaidsconsideringsexualpreferencesunderantiretroviraltherapyacasestudyinsanjuandepastocolombia
AT solartemarcoa mathematicalmodelofhivaidsconsideringsexualpreferencesunderantiretroviraltherapyacasestudyinsanjuandepastocolombia
AT hernandezivan mathematicalmodelofhivaidsconsideringsexualpreferencesunderantiretroviraltherapyacasestudyinsanjuandepastocolombia
AT riascosricardoa mathematicalmodelofhivaidsconsideringsexualpreferencesunderantiretroviraltherapyacasestudyinsanjuandepastocolombia
AT meyerjoaof mathematicalmodelofhivaidsconsideringsexualpreferencesunderantiretroviraltherapyacasestudyinsanjuandepastocolombia