Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies

Driven by the potential to broaden the target space of conventional monospecific antibodies, the field of multi-specific antibody derivatives is growing rapidly. The production and screening of these artificial proteins entails a high combinatorial complexity. Antibody-domain exchange was previously...

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Detalles Bibliográficos
Autores principales: Dickopf, Steffen, Buldun, Can, Vasic, Vedran, Georges, Guy, Hage, Carina, Mayer, Klaus, Forster, Matthias, Wessels, Uwe, Stubenrauch, Kay-Gunnar, Benz, Jörg, Ehler, Andreas, Lauer, Matthias E., Ringler, Philippe, Kobold, Sebastian, Endres, Stefan, Klein, Christian, Brinkmann, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125802/
https://www.ncbi.nlm.nih.gov/pubmed/35073465
http://dx.doi.org/10.1515/hsz-2021-0401

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