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Investigation of predictors of bleeding complications in COVID‐19 using rotational thromboelastometry (ROTEM(Ⓡ)): A retrospective study

BACKGROUND: Hemorrhagic complications in patients with coronavirus 19 disease (COVID‐19) are infrequent but associated with a prognosis. This study aimed to elucidate the risk factors for bleeding complications in patients with COVID‐19 using rotational thromboelastometry (ROTEM) parameters and bloo...

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Autores principales: Matsuoka, Ayaka, Koami, Hiroyuki, Shinada, Kota, Sasaki, Akira, Yamazaki, Hirotaka, Mori, Kosuke, Nakayama, Kento, Asahi, Miho, Yoshitake, Kunimasa, Narumi, Shogo, Koba, Mayuko, Kawaguchi, Atsushi, Sakamoto, Yuichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125870/
https://www.ncbi.nlm.nih.gov/pubmed/35620542
http://dx.doi.org/10.1002/hsr2.655
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author Matsuoka, Ayaka
Koami, Hiroyuki
Shinada, Kota
Sasaki, Akira
Yamazaki, Hirotaka
Mori, Kosuke
Nakayama, Kento
Asahi, Miho
Yoshitake, Kunimasa
Narumi, Shogo
Koba, Mayuko
Kawaguchi, Atsushi
Sakamoto, Yuichiro
author_facet Matsuoka, Ayaka
Koami, Hiroyuki
Shinada, Kota
Sasaki, Akira
Yamazaki, Hirotaka
Mori, Kosuke
Nakayama, Kento
Asahi, Miho
Yoshitake, Kunimasa
Narumi, Shogo
Koba, Mayuko
Kawaguchi, Atsushi
Sakamoto, Yuichiro
author_sort Matsuoka, Ayaka
collection PubMed
description BACKGROUND: Hemorrhagic complications in patients with coronavirus 19 disease (COVID‐19) are infrequent but associated with a prognosis. This study aimed to elucidate the risk factors for bleeding complications in patients with COVID‐19 using rotational thromboelastometry (ROTEM) parameters and blood tests performed at admission. METHODS: In total, 31 patients with severe COVID‐19 treated intensively at Saga University Hospital were included in this study. Patients were divided into two groups according to the presence or absence of hemorrhagic complications. Results from the blood tests performed at admission and during hospitalization, and ROTEM values acquired upon admission, were compared between the two groups. RESULTS: There were significant differences in ROTEM values upon admission between the bleeding and non‐bleeding groups. Receiver operating curve analysis showed that the area under the curve for prothrombin time international normalized ratio (PT‐INR) and extrinsically‐activated test with tissue factor (EXTEM) amplitude at 10 min (A10) were 0.82 (0.52–0.92) and 0.81 (0.58–0.93), respectively. Logistic regression analysis with PT‐INR and EXTEM A10 as factors calculated an odds ratio of 1.94 (1.04–3.62) and EXTEM A10 0.86 (0.71–1.05) for bleeding complications occurrence. CONCLUSION: ROTEM may be a sensitive predictor for bleeding complications in patients with COVID‐19.
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spelling pubmed-91258702022-05-25 Investigation of predictors of bleeding complications in COVID‐19 using rotational thromboelastometry (ROTEM(Ⓡ)): A retrospective study Matsuoka, Ayaka Koami, Hiroyuki Shinada, Kota Sasaki, Akira Yamazaki, Hirotaka Mori, Kosuke Nakayama, Kento Asahi, Miho Yoshitake, Kunimasa Narumi, Shogo Koba, Mayuko Kawaguchi, Atsushi Sakamoto, Yuichiro Health Sci Rep Original Research BACKGROUND: Hemorrhagic complications in patients with coronavirus 19 disease (COVID‐19) are infrequent but associated with a prognosis. This study aimed to elucidate the risk factors for bleeding complications in patients with COVID‐19 using rotational thromboelastometry (ROTEM) parameters and blood tests performed at admission. METHODS: In total, 31 patients with severe COVID‐19 treated intensively at Saga University Hospital were included in this study. Patients were divided into two groups according to the presence or absence of hemorrhagic complications. Results from the blood tests performed at admission and during hospitalization, and ROTEM values acquired upon admission, were compared between the two groups. RESULTS: There were significant differences in ROTEM values upon admission between the bleeding and non‐bleeding groups. Receiver operating curve analysis showed that the area under the curve for prothrombin time international normalized ratio (PT‐INR) and extrinsically‐activated test with tissue factor (EXTEM) amplitude at 10 min (A10) were 0.82 (0.52–0.92) and 0.81 (0.58–0.93), respectively. Logistic regression analysis with PT‐INR and EXTEM A10 as factors calculated an odds ratio of 1.94 (1.04–3.62) and EXTEM A10 0.86 (0.71–1.05) for bleeding complications occurrence. CONCLUSION: ROTEM may be a sensitive predictor for bleeding complications in patients with COVID‐19. John Wiley and Sons Inc. 2022-05-23 /pmc/articles/PMC9125870/ /pubmed/35620542 http://dx.doi.org/10.1002/hsr2.655 Text en © 2022 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Matsuoka, Ayaka
Koami, Hiroyuki
Shinada, Kota
Sasaki, Akira
Yamazaki, Hirotaka
Mori, Kosuke
Nakayama, Kento
Asahi, Miho
Yoshitake, Kunimasa
Narumi, Shogo
Koba, Mayuko
Kawaguchi, Atsushi
Sakamoto, Yuichiro
Investigation of predictors of bleeding complications in COVID‐19 using rotational thromboelastometry (ROTEM(Ⓡ)): A retrospective study
title Investigation of predictors of bleeding complications in COVID‐19 using rotational thromboelastometry (ROTEM(Ⓡ)): A retrospective study
title_full Investigation of predictors of bleeding complications in COVID‐19 using rotational thromboelastometry (ROTEM(Ⓡ)): A retrospective study
title_fullStr Investigation of predictors of bleeding complications in COVID‐19 using rotational thromboelastometry (ROTEM(Ⓡ)): A retrospective study
title_full_unstemmed Investigation of predictors of bleeding complications in COVID‐19 using rotational thromboelastometry (ROTEM(Ⓡ)): A retrospective study
title_short Investigation of predictors of bleeding complications in COVID‐19 using rotational thromboelastometry (ROTEM(Ⓡ)): A retrospective study
title_sort investigation of predictors of bleeding complications in covid‐19 using rotational thromboelastometry (rotem(ⓡ)): a retrospective study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125870/
https://www.ncbi.nlm.nih.gov/pubmed/35620542
http://dx.doi.org/10.1002/hsr2.655
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