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Exhaustion of CAR T cells: potential causes and solutions

Chimeric antigen receptor (CAR) T cell therapy has attracted attention for its promising therapeutic effects on hematological malignancies. However, there are problems such as relapse during long-term follow-up and limited effect on solid tumors with this therapy. Exhaustion, which impairs in vivo p...

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Detalles Bibliográficos
Autores principales:	Kouro, Taku, Himuro, Hidetomo, Sasada, Tetsuro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125881/ https://www.ncbi.nlm.nih.gov/pubmed/35606821 http://dx.doi.org/10.1186/s12967-022-03442-3

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