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D1/5 dopamine receptors are necessary for learning a novel context

Dopamine participates in encoding memories and could either encode rewarding/aversive value of unconditioned stimuli or act as a novelty signal triggering contextual learning. Here we show that intraperitoneal injection of the dopamine D1/5R antagonist SCH23390 impairs contextual fear conditioning a...

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Detalles Bibliográficos
Autores principales: Sayegh, Fares, Herraiz, Laurie, Colom, Morgane, Lopez, Sébastien, Rampon, Claire, Dahan, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126083/
https://www.ncbi.nlm.nih.gov/pubmed/35577394
http://dx.doi.org/10.1101/lm.053555.121