Cargando…
Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features
Differentiated thyroid tumors (DTC) are the most common indolent tumors associated with a good prognosis compared with other tumors. Its incidence during the last few decades has increased. DTC includes papillary carcinoma and follicular carcinoma. The BRAF is the most prevalent genetic mutation in...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126461/ https://www.ncbi.nlm.nih.gov/pubmed/35646190 http://dx.doi.org/10.25122/jml-2021-0415 |
_version_ | 1784712135329185792 |
---|---|
author | Wahid, Maha Hatem Abdul Almudhafar, Rihab Hameed |
author_facet | Wahid, Maha Hatem Abdul Almudhafar, Rihab Hameed |
author_sort | Wahid, Maha Hatem Abdul |
collection | PubMed |
description | Differentiated thyroid tumors (DTC) are the most common indolent tumors associated with a good prognosis compared with other tumors. Its incidence during the last few decades has increased. DTC includes papillary carcinoma and follicular carcinoma. The BRAF is the most prevalent genetic mutation in thyroid carcinoma, occurring in more than 50% of papillary thyroid cancers (PTCs). The study aimed to evaluate BRAF expression in differentiated thyroid tumors with papillary-like nuclear features. Formalin-fixed paraffin-embedded blocks (FFPE) were collected from archival samples of patients in private histopathology labs in Al-Najaf city from 55 cases, which included 27 papillary thyroid carcinoma (PTC) cases, 10 cases of NIFTP, 13 FVPTC cases, 2 papillary microcarcinoma cases, and 3 NIFTP coexist with papillary microcarcinoma cases. All samples were stained using the immunohistochemistry method in the Middle Euphrates unit for cancer research at the University of Kufa/Faculty of Medicine. 15/55 (27.3%) of cases increased BRAF expression. The BRAF expression was statistically significant with tumor type (p=0.008). The higher expression was associated with 13 (48.15%) of PTC cases. However, the BRAF expression did not correlate with gender (p=0.2), tumor size (p=0.07), and tumor focality (p=0.09). BRAF V600E has prognostic value as it correlates with tumor progression. |
format | Online Article Text |
id | pubmed-9126461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-91264612022-06-01 Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features Wahid, Maha Hatem Abdul Almudhafar, Rihab Hameed J Med Life Original Article Differentiated thyroid tumors (DTC) are the most common indolent tumors associated with a good prognosis compared with other tumors. Its incidence during the last few decades has increased. DTC includes papillary carcinoma and follicular carcinoma. The BRAF is the most prevalent genetic mutation in thyroid carcinoma, occurring in more than 50% of papillary thyroid cancers (PTCs). The study aimed to evaluate BRAF expression in differentiated thyroid tumors with papillary-like nuclear features. Formalin-fixed paraffin-embedded blocks (FFPE) were collected from archival samples of patients in private histopathology labs in Al-Najaf city from 55 cases, which included 27 papillary thyroid carcinoma (PTC) cases, 10 cases of NIFTP, 13 FVPTC cases, 2 papillary microcarcinoma cases, and 3 NIFTP coexist with papillary microcarcinoma cases. All samples were stained using the immunohistochemistry method in the Middle Euphrates unit for cancer research at the University of Kufa/Faculty of Medicine. 15/55 (27.3%) of cases increased BRAF expression. The BRAF expression was statistically significant with tumor type (p=0.008). The higher expression was associated with 13 (48.15%) of PTC cases. However, the BRAF expression did not correlate with gender (p=0.2), tumor size (p=0.07), and tumor focality (p=0.09). BRAF V600E has prognostic value as it correlates with tumor progression. Carol Davila University Press 2022-04 /pmc/articles/PMC9126461/ /pubmed/35646190 http://dx.doi.org/10.25122/jml-2021-0415 Text en ©2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Wahid, Maha Hatem Abdul Almudhafar, Rihab Hameed Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features |
title | Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features |
title_full | Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features |
title_fullStr | Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features |
title_full_unstemmed | Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features |
title_short | Comparative BRAF V600E immunohistochemical expression in differentiated thyroid tumors with papillary features |
title_sort | comparative braf v600e immunohistochemical expression in differentiated thyroid tumors with papillary features |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126461/ https://www.ncbi.nlm.nih.gov/pubmed/35646190 http://dx.doi.org/10.25122/jml-2021-0415 |
work_keys_str_mv | AT wahidmahahatemabdul comparativebrafv600eimmunohistochemicalexpressionindifferentiatedthyroidtumorswithpapillaryfeatures AT almudhafarrihabhameed comparativebrafv600eimmunohistochemicalexpressionindifferentiatedthyroidtumorswithpapillaryfeatures |