Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca(2+) signalling to control glucose-dependent insulin secretion

A developing understanding suggests that spatial compartmentalisation in pancreatic β cells is critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cell subcellular imaging methods using the mouse organotypic pancreatic slice. We demonstrate that the organ...

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Detalles Bibliográficos
Autores principales: Jevon, Dillon, Deng, Kylie, Hallahan, Nicole, Kumar, Krish, Tong, Jason, Gan, Wan Jun, Tran, Clara, Bilek, Marcela, Thorn, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126582/
https://www.ncbi.nlm.nih.gov/pubmed/35559734
http://dx.doi.org/10.7554/eLife.76262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126582/
https://www.ncbi.nlm.nih.gov/pubmed/35559734
http://dx.doi.org/10.7554/eLife.76262

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