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Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca(2+) signalling to control glucose-dependent insulin secretion
A developing understanding suggests that spatial compartmentalisation in pancreatic β cells is critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cell subcellular imaging methods using the mouse organotypic pancreatic slice. We demonstrate that the organ...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126582/ https://www.ncbi.nlm.nih.gov/pubmed/35559734 http://dx.doi.org/10.7554/eLife.76262 |