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Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study
OBJECTIVE: To evaluate anthropometric and clinical data, muscle mass, subcutaneous fat, spine bone mineral density, extent of acute pulmonary disease related to COVID-19, quantification of pulmonary emphysema, coronary calcium, and hepatic steatosis using chest computed tomography of hospitalized pa...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126606/ https://www.ncbi.nlm.nih.gov/pubmed/35649055 http://dx.doi.org/10.31744/einstein_journal/2022AO6953 |
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author | do Amaral e Castro, Adham Yokoo, Patrícia Fonseca, Eduardo Kaiser Ururahy Nunes Otoni, Jessyca Couto Haiek, Sarah Lustosa Shoji, Hamilton Chate, Rodrigo Caruso Pereira, Andrea Z de Queiroz, Marcos Roberto Gomes Batista, Marcelo Costa Szarf, Gilberto |
author_facet | do Amaral e Castro, Adham Yokoo, Patrícia Fonseca, Eduardo Kaiser Ururahy Nunes Otoni, Jessyca Couto Haiek, Sarah Lustosa Shoji, Hamilton Chate, Rodrigo Caruso Pereira, Andrea Z de Queiroz, Marcos Roberto Gomes Batista, Marcelo Costa Szarf, Gilberto |
author_sort | do Amaral e Castro, Adham |
collection | PubMed |
description | OBJECTIVE: To evaluate anthropometric and clinical data, muscle mass, subcutaneous fat, spine bone mineral density, extent of acute pulmonary disease related to COVID-19, quantification of pulmonary emphysema, coronary calcium, and hepatic steatosis using chest computed tomography of hospitalized patients with confirmed diagnosis of COVID-19 pneumonia and verify its association with disease severity. METHODS: A total of 123 adults hospitalized due to COVID-19 pneumonia were enrolled in the present study, which evaluated the anthropometric, clinical and chest computed tomography data (pectoral and paravertebral muscle area and density, subcutaneous fat, thoracic vertebral bodies density, degree of pulmonary involvement by disease, coronary calcium quantification, liver attenuation measurement) and their association with poorer prognosis characterized through a combined outcome of intubation and mechanical ventilation, need of intensive care unit, and death. RESULTS: Age (p=0.013), body mass index (p=0.009), lymphopenia (p=0.034), and degree of pulmonary involvement of COVID-19 pneumonia (p<0.001) were associated with poor prognosis. Extent of pulmonary involvement by COVID-19 pneumonia had an odds ratio of 1,329 for a poor prognosis and a cutoff value of 6.5 for increased risk, with a sensitivity of 64.9% and specificity of 67.1%. CONCLUSION: The present study found an association of high body mass index, older age, extent of pulmonary involvement by COVID-19, and lymphopenia with severity of COVID-19 pneumonia in hospitalized patients. |
format | Online Article Text |
id | pubmed-9126606 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
record_format | MEDLINE/PubMed |
spelling | pubmed-91266062022-05-26 Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study do Amaral e Castro, Adham Yokoo, Patrícia Fonseca, Eduardo Kaiser Ururahy Nunes Otoni, Jessyca Couto Haiek, Sarah Lustosa Shoji, Hamilton Chate, Rodrigo Caruso Pereira, Andrea Z de Queiroz, Marcos Roberto Gomes Batista, Marcelo Costa Szarf, Gilberto Einstein (Sao Paulo) Original Article OBJECTIVE: To evaluate anthropometric and clinical data, muscle mass, subcutaneous fat, spine bone mineral density, extent of acute pulmonary disease related to COVID-19, quantification of pulmonary emphysema, coronary calcium, and hepatic steatosis using chest computed tomography of hospitalized patients with confirmed diagnosis of COVID-19 pneumonia and verify its association with disease severity. METHODS: A total of 123 adults hospitalized due to COVID-19 pneumonia were enrolled in the present study, which evaluated the anthropometric, clinical and chest computed tomography data (pectoral and paravertebral muscle area and density, subcutaneous fat, thoracic vertebral bodies density, degree of pulmonary involvement by disease, coronary calcium quantification, liver attenuation measurement) and their association with poorer prognosis characterized through a combined outcome of intubation and mechanical ventilation, need of intensive care unit, and death. RESULTS: Age (p=0.013), body mass index (p=0.009), lymphopenia (p=0.034), and degree of pulmonary involvement of COVID-19 pneumonia (p<0.001) were associated with poor prognosis. Extent of pulmonary involvement by COVID-19 pneumonia had an odds ratio of 1,329 for a poor prognosis and a cutoff value of 6.5 for increased risk, with a sensitivity of 64.9% and specificity of 67.1%. CONCLUSION: The present study found an association of high body mass index, older age, extent of pulmonary involvement by COVID-19, and lymphopenia with severity of COVID-19 pneumonia in hospitalized patients. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2022-05-16 /pmc/articles/PMC9126606/ /pubmed/35649055 http://dx.doi.org/10.31744/einstein_journal/2022AO6953 Text en https://creativecommons.org/licenses/by/4.0/This content is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Original Article do Amaral e Castro, Adham Yokoo, Patrícia Fonseca, Eduardo Kaiser Ururahy Nunes Otoni, Jessyca Couto Haiek, Sarah Lustosa Shoji, Hamilton Chate, Rodrigo Caruso Pereira, Andrea Z de Queiroz, Marcos Roberto Gomes Batista, Marcelo Costa Szarf, Gilberto Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study |
title | Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study |
title_full | Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study |
title_fullStr | Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study |
title_full_unstemmed | Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study |
title_short | Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study |
title_sort | prognostic factors of worse outcome for hospitalized covid-19 patients, with emphasis on chest computed tomography data: a retrospective study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126606/ https://www.ncbi.nlm.nih.gov/pubmed/35649055 http://dx.doi.org/10.31744/einstein_journal/2022AO6953 |
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