The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis

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Recessive mutations in RNF216/TRIAD3 cause Gordon Holmes syndrome (GHS), in which dysfunction of the hypothalamic-pituitary-gonadal (HPG) axis and neurodegeneration are thought to be core phenotypes. We knocked out Rnf216/Triad3 in a gonadotropin-releasing hormone (GnRH) hypothalamic cell line. Rnf2...

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Detalles Bibliográficos
Autores principales: George, Arlene J., Dong, Bin, Lail, Hannah, Gomez, Morgan, Hoffiz, Yarely C., Ware, Christopher B., Fang, Ning, Murphy, Anne Z., Hrabovszky, Erik, Wanders, Desiree, Mabb, Angela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126796/
https://www.ncbi.nlm.nih.gov/pubmed/35620441
http://dx.doi.org/10.1016/j.isci.2022.104386
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