Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: DTNB and DLG2

Alzheimer’s disease (AD) is a genetically complex disease for which nearly 40 loci have now been identified via genome-wide association studies (GWAS). We attempted to identify groups of rare variants (alternate allele frequency <0.01) associated with AD in a region-based, whole-genome sequencing...

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Detalles Bibliográficos
Autores principales: Prokopenko, Dmitry, Lee, Sanghun, Hecker, Julian, Mullin, Kristina, Morgan, Sarah, Katsumata, Yuriko, Weiner, Michael W., Fardo, David W., Laird, Nan, Bertram, Lars, Hide, Winston, Lange, Christoph, Tanzi, Rudolph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126808/
https://www.ncbi.nlm.nih.gov/pubmed/35246634
http://dx.doi.org/10.1038/s41380-022-01475-0

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