Cargando…
Abnormal dynamic functional connectivity during fear extinction learning in PTSD and anxiety disorders
Examining the neural circuits of fear/threat extinction advanced our mechanistic understanding of several psychiatric disorders, including anxiety disorders (AX) and posttraumatic stress disorder (PTSD). More is needed to understand the interplay of large-scale neural networks during fear extinction...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126814/ https://www.ncbi.nlm.nih.gov/pubmed/35145227 http://dx.doi.org/10.1038/s41380-022-01462-5 |
_version_ | 1784712211568001024 |
---|---|
author | Wen, Zhenfu Seo, Jeehye Pace-Schott, Edward F. Milad, Mohammed R. |
author_facet | Wen, Zhenfu Seo, Jeehye Pace-Schott, Edward F. Milad, Mohammed R. |
author_sort | Wen, Zhenfu |
collection | PubMed |
description | Examining the neural circuits of fear/threat extinction advanced our mechanistic understanding of several psychiatric disorders, including anxiety disorders (AX) and posttraumatic stress disorder (PTSD). More is needed to understand the interplay of large-scale neural networks during fear extinction in these disorders. We used dynamic functional connectivity (FC) to study how FC might be perturbed during conditioned fear extinction in individuals with AX or PTSD. We analyzed neuroimaging data from 338 individuals that underwent a two-day fear conditioning and extinction paradigm. The sample included healthy controls (HC), trauma-exposed non-PTSD controls, and patients diagnosed with AX or PTSD. Dynamic FC during extinction learning gradually increased in the HC group but not in patient groups. The lack of FC change in patients was predominantly observed within and between the default mode, frontoparietal control, and somatomotor networks. The AX and PTSD groups showed impairments in different, yet partially overlapping connections especially involving the dorsolateral prefrontal cortex. Extinction-induced FC predicted ventromedial prefrontal cortex activation and FC during extinction memory recall only in the HC group. FC impairments during extinction learning correlated with fear- and anxiety-related clinical measures. These findings suggest that relative to controls, individuals with AX or PTSD exhibited widespread abnormal FC in higher-order cognitive and attention networks during extinction learning and failed to establish a link between neural signatures during extinction learning and memory retrieval. This failure might underlie abnormal processes related to the conscious awareness, attention allocation, and sensory processes during extinction learning and retrieval in fear- and anxiety-related disorders. |
format | Online Article Text |
id | pubmed-9126814 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91268142022-05-25 Abnormal dynamic functional connectivity during fear extinction learning in PTSD and anxiety disorders Wen, Zhenfu Seo, Jeehye Pace-Schott, Edward F. Milad, Mohammed R. Mol Psychiatry Article Examining the neural circuits of fear/threat extinction advanced our mechanistic understanding of several psychiatric disorders, including anxiety disorders (AX) and posttraumatic stress disorder (PTSD). More is needed to understand the interplay of large-scale neural networks during fear extinction in these disorders. We used dynamic functional connectivity (FC) to study how FC might be perturbed during conditioned fear extinction in individuals with AX or PTSD. We analyzed neuroimaging data from 338 individuals that underwent a two-day fear conditioning and extinction paradigm. The sample included healthy controls (HC), trauma-exposed non-PTSD controls, and patients diagnosed with AX or PTSD. Dynamic FC during extinction learning gradually increased in the HC group but not in patient groups. The lack of FC change in patients was predominantly observed within and between the default mode, frontoparietal control, and somatomotor networks. The AX and PTSD groups showed impairments in different, yet partially overlapping connections especially involving the dorsolateral prefrontal cortex. Extinction-induced FC predicted ventromedial prefrontal cortex activation and FC during extinction memory recall only in the HC group. FC impairments during extinction learning correlated with fear- and anxiety-related clinical measures. These findings suggest that relative to controls, individuals with AX or PTSD exhibited widespread abnormal FC in higher-order cognitive and attention networks during extinction learning and failed to establish a link between neural signatures during extinction learning and memory retrieval. This failure might underlie abnormal processes related to the conscious awareness, attention allocation, and sensory processes during extinction learning and retrieval in fear- and anxiety-related disorders. Nature Publishing Group UK 2022-02-10 2022 /pmc/articles/PMC9126814/ /pubmed/35145227 http://dx.doi.org/10.1038/s41380-022-01462-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Wen, Zhenfu Seo, Jeehye Pace-Schott, Edward F. Milad, Mohammed R. Abnormal dynamic functional connectivity during fear extinction learning in PTSD and anxiety disorders |
title | Abnormal dynamic functional connectivity during fear extinction learning in PTSD and anxiety disorders |
title_full | Abnormal dynamic functional connectivity during fear extinction learning in PTSD and anxiety disorders |
title_fullStr | Abnormal dynamic functional connectivity during fear extinction learning in PTSD and anxiety disorders |
title_full_unstemmed | Abnormal dynamic functional connectivity during fear extinction learning in PTSD and anxiety disorders |
title_short | Abnormal dynamic functional connectivity during fear extinction learning in PTSD and anxiety disorders |
title_sort | abnormal dynamic functional connectivity during fear extinction learning in ptsd and anxiety disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126814/ https://www.ncbi.nlm.nih.gov/pubmed/35145227 http://dx.doi.org/10.1038/s41380-022-01462-5 |
work_keys_str_mv | AT wenzhenfu abnormaldynamicfunctionalconnectivityduringfearextinctionlearninginptsdandanxietydisorders AT seojeehye abnormaldynamicfunctionalconnectivityduringfearextinctionlearninginptsdandanxietydisorders AT paceschottedwardf abnormaldynamicfunctionalconnectivityduringfearextinctionlearninginptsdandanxietydisorders AT miladmohammedr abnormaldynamicfunctionalconnectivityduringfearextinctionlearninginptsdandanxietydisorders |