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Lifespan extension with preservation of hippocampal function in aged system x(c)(−)-deficient male mice

The cystine/glutamate antiporter system x(c)(−) has been identified as the major source of extracellular glutamate in several brain regions as well as a modulator of neuroinflammation, and genetic deletion of its specific subunit xCT (xCT(−/−)) is protective in mouse models for age-related neurologi...

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Detalles Bibliográficos
Autores principales:	Verbruggen, Lise, Ates, Gamze, Lara, Olaya, De Munck, Jolien, Villers, Agnès, De Pauw, Laura, Ottestad-Hansen, Sigrid, Kobayashi, Sho, Beckers, Pauline, Janssen, Pauline, Sato, Hideyo, Zhou, Yun, Hermans, Emmanuel, Njemini, Rose, Arckens, Lutgarde, Danbolt, Niels C., De Bundel, Dimitri, Aerts, Joeri L., Barbé, Kurt, Guillaume, Benoit, Ris, Laurence, Bentea, Eduard, Massie, Ann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126817/ https://www.ncbi.nlm.nih.gov/pubmed/35181756 http://dx.doi.org/10.1038/s41380-022-01470-5

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