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Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium
Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls, affecting widespread cortical regions. The possible impacts of these regional alterations in terms of...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126820/ https://www.ncbi.nlm.nih.gov/pubmed/35136228 http://dx.doi.org/10.1038/s41380-022-01452-7 |
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author | Sha, Zhiqiang van Rooij, Daan Anagnostou, Evdokia Arango, Celso Auzias, Guillaume Behrmann, Marlene Bernhardt, Boris Bolte, Sven Busatto, Geraldo F. Calderoni, Sara Calvo, Rosa Daly, Eileen Deruelle, Christine Duan, Meiyu Duran, Fabio Luis Souza Durston, Sarah Ecker, Christine Ehrlich, Stefan Fair, Damien Fedor, Jennifer Fitzgerald, Jacqueline Floris, Dorothea L. Franke, Barbara Freitag, Christine M. Gallagher, Louise Glahn, David C. Haar, Shlomi Hoekstra, Liesbeth Jahanshad, Neda Jalbrzikowski, Maria Janssen, Joost King, Joseph A. Lazaro, Luisa Luna, Beatriz McGrath, Jane Medland, Sarah E. Muratori, Filippo Murphy, Declan G. M. Neufeld, Janina O’Hearn, Kirsten Oranje, Bob Parellada, Mara Pariente, Jose C. Postema, Merel C. Remnelius, Karl Lundin Retico, Alessandra Rosa, Pedro Gomes Penteado Rubia, Katya Shook, Devon Tammimies, Kristiina Taylor, Margot J. Tosetti, Michela Wallace, Gregory L. Zhou, Fengfeng Thompson, Paul M. Fisher, Simon E. Buitelaar, Jan K. Francks, Clyde |
author_facet | Sha, Zhiqiang van Rooij, Daan Anagnostou, Evdokia Arango, Celso Auzias, Guillaume Behrmann, Marlene Bernhardt, Boris Bolte, Sven Busatto, Geraldo F. Calderoni, Sara Calvo, Rosa Daly, Eileen Deruelle, Christine Duan, Meiyu Duran, Fabio Luis Souza Durston, Sarah Ecker, Christine Ehrlich, Stefan Fair, Damien Fedor, Jennifer Fitzgerald, Jacqueline Floris, Dorothea L. Franke, Barbara Freitag, Christine M. Gallagher, Louise Glahn, David C. Haar, Shlomi Hoekstra, Liesbeth Jahanshad, Neda Jalbrzikowski, Maria Janssen, Joost King, Joseph A. Lazaro, Luisa Luna, Beatriz McGrath, Jane Medland, Sarah E. Muratori, Filippo Murphy, Declan G. M. Neufeld, Janina O’Hearn, Kirsten Oranje, Bob Parellada, Mara Pariente, Jose C. Postema, Merel C. Remnelius, Karl Lundin Retico, Alessandra Rosa, Pedro Gomes Penteado Rubia, Katya Shook, Devon Tammimies, Kristiina Taylor, Margot J. Tosetti, Michela Wallace, Gregory L. Zhou, Fengfeng Thompson, Paul M. Fisher, Simon E. Buitelaar, Jan K. Francks, Clyde |
author_sort | Sha, Zhiqiang |
collection | PubMed |
description | Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls, affecting widespread cortical regions. The possible impacts of these regional alterations in terms of structural network effects have not previously been characterized. Inter-regional morphological covariance analysis can capture network connectivity between different cortical areas at the macroscale level. Here, we used cortical thickness data from 1455 individuals with ASD and 1560 controls, across 43 independent datasets of the ENIGMA consortium’s ASD Working Group, to assess hemispheric asymmetries of intra-individual structural covariance networks, using graph theory-based topological metrics. Compared with typical features of small-world architecture in controls, the ASD sample showed significantly altered average asymmetry of networks involving the fusiform, rostral middle frontal, and medial orbitofrontal cortex, involving higher randomization of the corresponding right-hemispheric networks in ASD. A network involving the superior frontal cortex showed decreased right-hemisphere randomization. Based on comparisons with meta-analyzed functional neuroimaging data, the altered connectivity asymmetry particularly affected networks that subserve executive functions, language-related and sensorimotor processes. These findings provide a network-level characterization of altered left-right brain asymmetry in ASD, based on a large combined sample. Altered asymmetrical brain development in ASD may be partly propagated among spatially distant regions through structural connectivity. |
format | Online Article Text |
id | pubmed-9126820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91268202022-05-25 Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium Sha, Zhiqiang van Rooij, Daan Anagnostou, Evdokia Arango, Celso Auzias, Guillaume Behrmann, Marlene Bernhardt, Boris Bolte, Sven Busatto, Geraldo F. Calderoni, Sara Calvo, Rosa Daly, Eileen Deruelle, Christine Duan, Meiyu Duran, Fabio Luis Souza Durston, Sarah Ecker, Christine Ehrlich, Stefan Fair, Damien Fedor, Jennifer Fitzgerald, Jacqueline Floris, Dorothea L. Franke, Barbara Freitag, Christine M. Gallagher, Louise Glahn, David C. Haar, Shlomi Hoekstra, Liesbeth Jahanshad, Neda Jalbrzikowski, Maria Janssen, Joost King, Joseph A. Lazaro, Luisa Luna, Beatriz McGrath, Jane Medland, Sarah E. Muratori, Filippo Murphy, Declan G. M. Neufeld, Janina O’Hearn, Kirsten Oranje, Bob Parellada, Mara Pariente, Jose C. Postema, Merel C. Remnelius, Karl Lundin Retico, Alessandra Rosa, Pedro Gomes Penteado Rubia, Katya Shook, Devon Tammimies, Kristiina Taylor, Margot J. Tosetti, Michela Wallace, Gregory L. Zhou, Fengfeng Thompson, Paul M. Fisher, Simon E. Buitelaar, Jan K. Francks, Clyde Mol Psychiatry Article Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls, affecting widespread cortical regions. The possible impacts of these regional alterations in terms of structural network effects have not previously been characterized. Inter-regional morphological covariance analysis can capture network connectivity between different cortical areas at the macroscale level. Here, we used cortical thickness data from 1455 individuals with ASD and 1560 controls, across 43 independent datasets of the ENIGMA consortium’s ASD Working Group, to assess hemispheric asymmetries of intra-individual structural covariance networks, using graph theory-based topological metrics. Compared with typical features of small-world architecture in controls, the ASD sample showed significantly altered average asymmetry of networks involving the fusiform, rostral middle frontal, and medial orbitofrontal cortex, involving higher randomization of the corresponding right-hemispheric networks in ASD. A network involving the superior frontal cortex showed decreased right-hemisphere randomization. Based on comparisons with meta-analyzed functional neuroimaging data, the altered connectivity asymmetry particularly affected networks that subserve executive functions, language-related and sensorimotor processes. These findings provide a network-level characterization of altered left-right brain asymmetry in ASD, based on a large combined sample. Altered asymmetrical brain development in ASD may be partly propagated among spatially distant regions through structural connectivity. Nature Publishing Group UK 2022-02-08 2022 /pmc/articles/PMC9126820/ /pubmed/35136228 http://dx.doi.org/10.1038/s41380-022-01452-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Sha, Zhiqiang van Rooij, Daan Anagnostou, Evdokia Arango, Celso Auzias, Guillaume Behrmann, Marlene Bernhardt, Boris Bolte, Sven Busatto, Geraldo F. Calderoni, Sara Calvo, Rosa Daly, Eileen Deruelle, Christine Duan, Meiyu Duran, Fabio Luis Souza Durston, Sarah Ecker, Christine Ehrlich, Stefan Fair, Damien Fedor, Jennifer Fitzgerald, Jacqueline Floris, Dorothea L. Franke, Barbara Freitag, Christine M. Gallagher, Louise Glahn, David C. Haar, Shlomi Hoekstra, Liesbeth Jahanshad, Neda Jalbrzikowski, Maria Janssen, Joost King, Joseph A. Lazaro, Luisa Luna, Beatriz McGrath, Jane Medland, Sarah E. Muratori, Filippo Murphy, Declan G. M. Neufeld, Janina O’Hearn, Kirsten Oranje, Bob Parellada, Mara Pariente, Jose C. Postema, Merel C. Remnelius, Karl Lundin Retico, Alessandra Rosa, Pedro Gomes Penteado Rubia, Katya Shook, Devon Tammimies, Kristiina Taylor, Margot J. Tosetti, Michela Wallace, Gregory L. Zhou, Fengfeng Thompson, Paul M. Fisher, Simon E. Buitelaar, Jan K. Francks, Clyde Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium |
title | Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium |
title_full | Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium |
title_fullStr | Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium |
title_full_unstemmed | Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium |
title_short | Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium |
title_sort | subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the enigma consortium |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126820/ https://www.ncbi.nlm.nih.gov/pubmed/35136228 http://dx.doi.org/10.1038/s41380-022-01452-7 |
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