Matrix stiffness mediates pancreatic cancer chemoresistance through induction of exosome hypersecretion in a cancer associated fibroblasts-tumor organoid biomimetic model

In pancreatic ductal adenocarcinoma (PDAC), the abundant stromal cells which comprise the tumor microenvironment constitute more than 90% of the primary tumor bulk. Moreover, this desmoplastic environment has been found to be three times stiffer than normal pancreas tissue. Despite the importance of...

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Detalles Bibliográficos
Autores principales: Xiao, Weikun, Pahlavanneshan, Mahsa, Eun, Chae-Young, Zhang, Xinyu, DeKalb, Charlene, Mahgoub, Bayan, Knaneh-Monem, Hanaa, Shah, Sana, Sohrabi, Alireza, Seidlits, Stephanie K., Hill, Reginald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126837/
https://www.ncbi.nlm.nih.gov/pubmed/35619988
http://dx.doi.org/10.1016/j.mbplus.2022.100111

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