Cargando…

Quality of Life and Its Determinants in Liver Transplantation Candidates: A Missed Link in Liver Care Program during the Waiting Time for Liver Transplantation

BACKGROUND: The health-related quality of life (HRQOL) in the before liver transplantation (LT) stage has not been studied as much as that after the LT stage. We aimed to assess HRQOL and its determinants before the LT stage. METHODS: As a cross-sectional study, HRQOL of all adult patients (n=632) r...

Descripción completa

Detalles Bibliográficos
Autores principales: Bagheri Lankarani, Kamran, Honarvar, Behnam, Akbari, Mahsa, Bozorgnia, Naghmeh, Rabiey Faradonbeh, Maryam, Bagherpour, Morteza, Nikeghbalian, Saman, Shamsaeefar, Alireza, Malekhosseini, Seyed Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126895/
https://www.ncbi.nlm.nih.gov/pubmed/35634527
http://dx.doi.org/10.30476/IJMS.2021.88302.1895
_version_ 1784712229775474688
author Bagheri Lankarani, Kamran
Honarvar, Behnam
Akbari, Mahsa
Bozorgnia, Naghmeh
Rabiey Faradonbeh, Maryam
Bagherpour, Morteza
Nikeghbalian, Saman
Shamsaeefar, Alireza
Malekhosseini, Seyed Ali
author_facet Bagheri Lankarani, Kamran
Honarvar, Behnam
Akbari, Mahsa
Bozorgnia, Naghmeh
Rabiey Faradonbeh, Maryam
Bagherpour, Morteza
Nikeghbalian, Saman
Shamsaeefar, Alireza
Malekhosseini, Seyed Ali
author_sort Bagheri Lankarani, Kamran
collection PubMed
description BACKGROUND: The health-related quality of life (HRQOL) in the before liver transplantation (LT) stage has not been studied as much as that after the LT stage. We aimed to assess HRQOL and its determinants before the LT stage. METHODS: As a cross-sectional study, HRQOL of all adult patients (n=632) referred to the LT center of Shiraz, Iran in 2018-2019 were assessed. Demographic, socioeconomic, medical, and paraclinical data were requested. Physical (PCS) and mental (MCS) aspects of HRQOL were assessed using the SF36 questionnaire. Univariable, multivariable (linear regression), and confirmatory factor analysis were performed utilizing SPSS 20 and Mplus 6.1 software. P<0.05 was considered to be significant. RESULTS: The mean age of the patients was 47.6±12.3 years, while 414 (65.6%) were men, and the mean, score of the model for end-stage liver disease (MELD) was 18.36±5.58. The mean score of QOL, PCS, and MCS was 50.01±21.73, 46.23±23.23, and 53.78±23.91 (out of 100), respectively. Vitality had the most association with HRQOL, while role limitations had the lowest. The multivariable analysis revealed that unemployment (P<0.001), anemia (P=0.005), weight loss (P=0.005), diabetes mellitus (DM) (P=0.009), low MELD score (P=0.027), and drug use (P=0.03) were the significant determinants of HRQOL, respectively. CONCLUSION: The present study showed that HRQOL in the LT candidates was at the intermediate level, while their PCS and MCS are at the low and moderate levels, respectively. Furthermore, physical performance, job status, anemia, weight loss, MELD score, DM, and drug use should be considered as the significant determinants of HRQOL in the LT candidates.
format Online
Article
Text
id pubmed-9126895
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Shiraz University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-91268952022-05-26 Quality of Life and Its Determinants in Liver Transplantation Candidates: A Missed Link in Liver Care Program during the Waiting Time for Liver Transplantation Bagheri Lankarani, Kamran Honarvar, Behnam Akbari, Mahsa Bozorgnia, Naghmeh Rabiey Faradonbeh, Maryam Bagherpour, Morteza Nikeghbalian, Saman Shamsaeefar, Alireza Malekhosseini, Seyed Ali Iran J Med Sci Original Article BACKGROUND: The health-related quality of life (HRQOL) in the before liver transplantation (LT) stage has not been studied as much as that after the LT stage. We aimed to assess HRQOL and its determinants before the LT stage. METHODS: As a cross-sectional study, HRQOL of all adult patients (n=632) referred to the LT center of Shiraz, Iran in 2018-2019 were assessed. Demographic, socioeconomic, medical, and paraclinical data were requested. Physical (PCS) and mental (MCS) aspects of HRQOL were assessed using the SF36 questionnaire. Univariable, multivariable (linear regression), and confirmatory factor analysis were performed utilizing SPSS 20 and Mplus 6.1 software. P<0.05 was considered to be significant. RESULTS: The mean age of the patients was 47.6±12.3 years, while 414 (65.6%) were men, and the mean, score of the model for end-stage liver disease (MELD) was 18.36±5.58. The mean score of QOL, PCS, and MCS was 50.01±21.73, 46.23±23.23, and 53.78±23.91 (out of 100), respectively. Vitality had the most association with HRQOL, while role limitations had the lowest. The multivariable analysis revealed that unemployment (P<0.001), anemia (P=0.005), weight loss (P=0.005), diabetes mellitus (DM) (P=0.009), low MELD score (P=0.027), and drug use (P=0.03) were the significant determinants of HRQOL, respectively. CONCLUSION: The present study showed that HRQOL in the LT candidates was at the intermediate level, while their PCS and MCS are at the low and moderate levels, respectively. Furthermore, physical performance, job status, anemia, weight loss, MELD score, DM, and drug use should be considered as the significant determinants of HRQOL in the LT candidates. Shiraz University of Medical Sciences 2022-05 /pmc/articles/PMC9126895/ /pubmed/35634527 http://dx.doi.org/10.30476/IJMS.2021.88302.1895 Text en Copyright: © Iranian Journal of Medical Sciences https://creativecommons.org/licenses/by-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bagheri Lankarani, Kamran
Honarvar, Behnam
Akbari, Mahsa
Bozorgnia, Naghmeh
Rabiey Faradonbeh, Maryam
Bagherpour, Morteza
Nikeghbalian, Saman
Shamsaeefar, Alireza
Malekhosseini, Seyed Ali
Quality of Life and Its Determinants in Liver Transplantation Candidates: A Missed Link in Liver Care Program during the Waiting Time for Liver Transplantation
title Quality of Life and Its Determinants in Liver Transplantation Candidates: A Missed Link in Liver Care Program during the Waiting Time for Liver Transplantation
title_full Quality of Life and Its Determinants in Liver Transplantation Candidates: A Missed Link in Liver Care Program during the Waiting Time for Liver Transplantation
title_fullStr Quality of Life and Its Determinants in Liver Transplantation Candidates: A Missed Link in Liver Care Program during the Waiting Time for Liver Transplantation
title_full_unstemmed Quality of Life and Its Determinants in Liver Transplantation Candidates: A Missed Link in Liver Care Program during the Waiting Time for Liver Transplantation
title_short Quality of Life and Its Determinants in Liver Transplantation Candidates: A Missed Link in Liver Care Program during the Waiting Time for Liver Transplantation
title_sort quality of life and its determinants in liver transplantation candidates: a missed link in liver care program during the waiting time for liver transplantation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126895/
https://www.ncbi.nlm.nih.gov/pubmed/35634527
http://dx.doi.org/10.30476/IJMS.2021.88302.1895
work_keys_str_mv AT bagherilankaranikamran qualityoflifeanditsdeterminantsinlivertransplantationcandidatesamissedlinkinlivercareprogramduringthewaitingtimeforlivertransplantation
AT honarvarbehnam qualityoflifeanditsdeterminantsinlivertransplantationcandidatesamissedlinkinlivercareprogramduringthewaitingtimeforlivertransplantation
AT akbarimahsa qualityoflifeanditsdeterminantsinlivertransplantationcandidatesamissedlinkinlivercareprogramduringthewaitingtimeforlivertransplantation
AT bozorgnianaghmeh qualityoflifeanditsdeterminantsinlivertransplantationcandidatesamissedlinkinlivercareprogramduringthewaitingtimeforlivertransplantation
AT rabieyfaradonbehmaryam qualityoflifeanditsdeterminantsinlivertransplantationcandidatesamissedlinkinlivercareprogramduringthewaitingtimeforlivertransplantation
AT bagherpourmorteza qualityoflifeanditsdeterminantsinlivertransplantationcandidatesamissedlinkinlivercareprogramduringthewaitingtimeforlivertransplantation
AT nikeghbaliansaman qualityoflifeanditsdeterminantsinlivertransplantationcandidatesamissedlinkinlivercareprogramduringthewaitingtimeforlivertransplantation
AT shamsaeefaralireza qualityoflifeanditsdeterminantsinlivertransplantationcandidatesamissedlinkinlivercareprogramduringthewaitingtimeforlivertransplantation
AT malekhosseiniseyedali qualityoflifeanditsdeterminantsinlivertransplantationcandidatesamissedlinkinlivercareprogramduringthewaitingtimeforlivertransplantation