An increase in surface hydrophobicity mediates chaperone activity in N-chlorinated RidA

Under physiological conditions, Escherichia coli RidA is an enamine/imine deaminase, which promotes the release of ammonia from reactive enamine/imine intermediates. However, when modified by hypochlorous acid (HOCl), it turns into a potent chaperone-like holdase that can effectively protect E. coli...

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Detalles Bibliográficos
Autores principales: Varatnitskaya, Marharyta, Fasel, Julia, Müller, Alexandra, Lupilov, Natalie, Shi, Yunlong, Fuchs, Kristin, Krewing, Marco, Jung, Christoph, Jacob, Timo, Sitek, Barbara, Bandow, Julia E., Carroll, Kate S., Hofmann, Eckhard, Leichert, Lars I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126958/
https://www.ncbi.nlm.nih.gov/pubmed/35598378
http://dx.doi.org/10.1016/j.redox.2022.102332

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