Metabolic regulation by the intestinal metformin-AMPK axis

AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of Nature Communications, Zhang and colleagues reported that intestinal epithelium-specific AMPKα1 knockout mice fail to respond to...

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Autores principales: Zhang, Song-Yang, Lam, Tony K. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126964/
https://www.ncbi.nlm.nih.gov/pubmed/35606343
http://dx.doi.org/10.1038/s41467-022-30477-3
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author Zhang, Song-Yang
Lam, Tony K. T.
author_facet Zhang, Song-Yang
Lam, Tony K. T.
author_sort Zhang, Song-Yang
collection PubMed
description AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of Nature Communications, Zhang and colleagues reported that intestinal epithelium-specific AMPKα1 knockout mice fail to respond to metformin and exhibit disruption in metabolic homeostasis secondary to changes in the gut microbiome. This highlights a therapeutic potential of targeting intestinal AMPK for diabetes.
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spelling pubmed-91269642022-05-25 Metabolic regulation by the intestinal metformin-AMPK axis Zhang, Song-Yang Lam, Tony K. T. Nat Commun Comment AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of Nature Communications, Zhang and colleagues reported that intestinal epithelium-specific AMPKα1 knockout mice fail to respond to metformin and exhibit disruption in metabolic homeostasis secondary to changes in the gut microbiome. This highlights a therapeutic potential of targeting intestinal AMPK for diabetes. Nature Publishing Group UK 2022-05-23 /pmc/articles/PMC9126964/ /pubmed/35606343 http://dx.doi.org/10.1038/s41467-022-30477-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Zhang, Song-Yang
Lam, Tony K. T.
Metabolic regulation by the intestinal metformin-AMPK axis
title Metabolic regulation by the intestinal metformin-AMPK axis
title_full Metabolic regulation by the intestinal metformin-AMPK axis
title_fullStr Metabolic regulation by the intestinal metformin-AMPK axis
title_full_unstemmed Metabolic regulation by the intestinal metformin-AMPK axis
title_short Metabolic regulation by the intestinal metformin-AMPK axis
title_sort metabolic regulation by the intestinal metformin-ampk axis
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126964/
https://www.ncbi.nlm.nih.gov/pubmed/35606343
http://dx.doi.org/10.1038/s41467-022-30477-3
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