Cargando…

Metabolic regulation by the intestinal metformin-AMPK axis

AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of Nature Communications, Zhang and colleagues reported that intestinal epithelium-specific AMPKα1 knockout mice fail to respond to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Song-Yang, Lam, Tony K. T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Comment
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126964/ https://www.ncbi.nlm.nih.gov/pubmed/35606343 http://dx.doi.org/10.1038/s41467-022-30477-3

Ejemplares similares

Metformin attenuates diabetic renal injury via the AMPK-autophagy axis
por: Sun, Tingli, et al.
Publicado: (2021)

AMPK/Ulk1-dependent autophagy as a key mTOR regulator in the context of cell pluripotency
por: Suvorova, Irina I., et al.
Publicado: (2019)

Metformin: an inexpensive and effective treatment in people with diabetes and COVID-19?
por: Dardano, Angela, et al.
Publicado: (2021)

Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis
por: Liu, Bingli, et al.
Publicado: (2023)

Demystifying the Relationship Between Metformin, AMPK, and Doxorubicin Cardiotoxicity
por: Singh, Manrose, et al.
Publicado: (2022)

Comment on López-Yerena et al. “Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats” Pharmaceutics 2020, 12, 134
por: Kaddoumi, Amal, et al.
Publicado: (2020)

Metformin regulates myoblast differentiation through an AMPK-dependent mechanism
por: Maniscalco, Eleonora, et al.
Publicado: (2023)

“Metformin Impairs Intestinal Fructose Metabolism”
por: Tong, Wenxin, et al.
Publicado: (2023)

Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin
por: Chen, Lu, et al.
Publicado: (2018)

Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats
por: Tseng, Yi-Tang
Publicado: (2016)

First Successful Isolated Intestinal Transplant in a Brazilian Series
por: Andraus, Wellington, et al.
Publicado: (2021)

The immunological interplay between vaccination and the intestinal microbiota
por: Zimmermann, Petra
Publicado: (2023)

Could Pirfenidone Also be Effective in Treating Intestinal Fibrosis?
por: Latella, Giovanni, et al.
Publicado: (2020)

The role of intestinal microbiota in the pathogenesis of NAFLD: starting points for intervention
por: Vespasiani-Gentilucci, Umberto, et al.
Publicado: (2016)

Comment on “ILC1 drive intestinal epithelial and matrix remodeling”
por: Hariss, Fatima, et al.
Publicado: (2021)

The pivotal role of the angiotensin-II–NF-κB axis in the development of COVID-19 pathophysiology
por: Okamoto, Hiroshi, et al.
Publicado: (2020)

Comment on Chen et al. Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin. Biomolecules 2021, 11, 1373
por: Stransky, Nicolai, et al.
Publicado: (2022)

Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway
por: Bai, Fan, et al.
Publicado: (2019)

Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
por: Feng, Xiaofeng, et al.
Publicado: (2020)

Metformin-activated AMPK regulates β-catenin to reduce cell proliferation in colon carcinoma RKO cells
por: Park, Song Yi, et al.
Publicado: (2019)

Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis
por: Ji, Huimin, et al.
Publicado: (2023)

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
por: Agius, Loranne, et al.
Publicado: (2020)

A gut feeling for drugs that have metabolic benefits
por: Zhang, Eryun, et al.
Publicado: (2023)

Small intestinal taurochenodeoxycholic acid-FXR axis alters local nutrient-sensing glucoregulatory pathways in rats
por: Waise, T.M. Zaved, et al.
Publicado: (2020)

A negative trial for vasoactive intestinal peptide in COVID-19-associated acute hypoxaemic respiratory failure
por: Lee, Warren L, et al.
Publicado: (2023)

FERONIA and reactive oxygen species: regulators in the self-incompatibility response and in interspecific pollination
por: Song, Zihan, et al.
Publicado: (2023)

Metabolic adaptation to hypoxia: do worms and cancer cells share common metabolic responses to hypoxic stress?
por: Baumeister, Ralf, et al.
Publicado: (2021)

Pseudodiabetes—not a contraindication for metabolic interventions
por: Bravo-San Pedro, José Manuel, et al.
Publicado: (2019)

Endocrine and metabolic link to coronavirus infection
por: Bornstein, Stefan R., et al.
Publicado: (2020)

The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome
por: Lee, Seung Baek, et al.
Publicado: (2019)

Metformin protects against intestinal barrier dysfunction via AMPKα1‐dependent inhibition of JNK signalling activation
por: Deng, Jun, et al.
Publicado: (2017)

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
por: Chen, Suet Ching, et al.
Publicado: (2017)

Low-dose metformin targets the lysosomal AMPK pathway through PEN2
por: Ma, Teng, et al.
Publicado: (2022)

Ensuring continuity of care for children with inherited metabolic diseases at the time of COVID-19: the experience of a metabolic unit in Italy
por: Brunetti-Pierri, Nicola, et al.
Publicado: (2020)

Causality in dietary interventions—building a case for gut microbiota
por: Lam, Yan Y., et al.
Publicado: (2018)

Metformin enhances the chemosensitivity of hepatocarcinoma cells to cisplatin through AMPK pathway
por: Dong, Hao, et al.
Publicado: (2017)

A metabolic perspective into antimicrobial tolerance and resistance
por: Bhusal, Ram Prasad, et al.
Publicado: (2022)

Glutamine metabolism, the Achilles heel for medulloblastoma tumor
por: Niklison-Chirou, Maria Victoria
Publicado: (2018)

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
por: Groenendijk, Floris H, et al.
Publicado: (2015)

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK
por: Wang, Yu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_bli7iq5gge1ctpvuh0q5e6gvbn