Focal adhesion kinase inhibitors prevent osteoblast mineralization in part due to suppression of Akt-mediated stabilization of osterix

Focal Adhesion Kinase (FAK) is an important regulator of tumor cell proliferation, survival and metastasis. As such it has become a therapeutic target of interest in cancer. Previous studies suggested that use of FAK tyrosine kinase inhibitors (TKIs) blocks osteolysis in in vivo models of bone metas...

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Detalles Bibliográficos
Autores principales: Gunn, Scott A., Kreps, Lauren M., Zhao, Huijun, Landon, Katelyn, Ilacqua, Jacob S., Addison, Christina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126966/
https://www.ncbi.nlm.nih.gov/pubmed/35620245
http://dx.doi.org/10.1016/j.jbo.2022.100432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126966/
https://www.ncbi.nlm.nih.gov/pubmed/35620245
http://dx.doi.org/10.1016/j.jbo.2022.100432

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