p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis

Current therapy against colorectal cancer (CRC) is based on DNA-damaging agents that remain ineffective in a proportion of patients. Whether and how non-curative DNA damage-based treatment affects tumor cell behavior and patient outcome is primarily unstudied. Using CRC patient-derived organoids (PD...

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Detalles Bibliográficos
Autores principales: Solé, Laura, Lobo-Jarne, Teresa, Álvarez-Villanueva, Daniel, Alonso-Marañón, Josune, Guillén, Yolanda, Guix, Marta, Sangrador, Irene, Rozalén, Catalina, Vert, Anna, Barbachano, Antonio, Lop, Joan, Salido, Marta, Bellosillo, Beatriz, García-Romero, Raquel, Garrido, Marta, González, Jessica, Martínez-Iniesta, María, López-Arribillaga, Erika, Salazar, Ramón, Montagut, Clara, Torres, Ferrán, Iglesias, Mar, Celià-Terrassa, Toni, Muñoz, Alberto, Villanueva, Alberto, Bigas, Anna, Espinosa, Lluís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126967/
https://www.ncbi.nlm.nih.gov/pubmed/35606354
http://dx.doi.org/10.1038/s41467-022-30382-9

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