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Origins of direction selectivity in the primate retina

From mouse to primate, there is a striking discontinuity in our current understanding of the neural coding of motion direction. In non-primate mammals, directionally selective cell types and circuits are a signature feature of the retina, situated at the earliest stage of the visual process. In prim...

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Detalles Bibliográficos
Autores principales: Kim, Yeon Jin, Peterson, Beth B., Crook, Joanna D., Joo, Hannah R., Wu, Jiajia, Puller, Christian, Robinson, Farrel R., Gamlin, Paul D., Yau, King-Wai, Viana, Felix, Troy, John B., Smith, Robert G., Packer, Orin S., Detwiler, Peter B., Dacey, Dennis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126974/
https://www.ncbi.nlm.nih.gov/pubmed/35606344
http://dx.doi.org/10.1038/s41467-022-30405-5
Descripción
Sumario:From mouse to primate, there is a striking discontinuity in our current understanding of the neural coding of motion direction. In non-primate mammals, directionally selective cell types and circuits are a signature feature of the retina, situated at the earliest stage of the visual process. In primates, by contrast, direction selectivity is a hallmark of motion processing areas in visual cortex, but has not been found in the retina, despite significant effort. Here we combined functional recordings of light-evoked responses and connectomic reconstruction to identify diverse direction-selective cell types in the macaque monkey retina with distinctive physiological properties and synaptic motifs. This circuitry includes an ON-OFF ganglion cell type, a spiking, ON-OFF polyaxonal amacrine cell and the starburst amacrine cell, all of which show direction selectivity. Moreover, we discovered that macaque starburst cells possess a strong, non-GABAergic, antagonistic surround mediated by input from excitatory bipolar cells that is critical for the generation of radial motion sensitivity in these cells. Our findings open a door to investigation of a precortical circuitry that computes motion direction in the primate visual system.