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The Involvement of Long Non-Coding RNAs in Glioma: From Early Detection to Immunotherapy
Glioma is a brain tumor that arises in the central nervous system and is categorized according to histology and molecular genetic characteristics. Long non-coding RNAs (lncRNAs) are RNAs longer than 200 nucleotides in length. They have been reported to influence significant events such as carcinogen...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127066/ https://www.ncbi.nlm.nih.gov/pubmed/35619711 http://dx.doi.org/10.3389/fimmu.2022.897754 |
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author | Wu, Xiaoben Yang, Lei Wang, Jing Hao, Yingying Wang, Changyin Lu, Zhiming |
author_facet | Wu, Xiaoben Yang, Lei Wang, Jing Hao, Yingying Wang, Changyin Lu, Zhiming |
author_sort | Wu, Xiaoben |
collection | PubMed |
description | Glioma is a brain tumor that arises in the central nervous system and is categorized according to histology and molecular genetic characteristics. Long non-coding RNAs (lncRNAs) are RNAs longer than 200 nucleotides in length. They have been reported to influence significant events such as carcinogenesis, progression, and increased treatment resistance on glioma cells. Long non-coding RNAs promote cell proliferation, migration, epithelial-to-mesenchymal transition and invasion in glioma cells. Various significant advancements in transcriptomic profiling studies have enabled the identification of immune-related long non-coding RNAs as immune cell-specific gene expression regulators that mediates both stimulatory and suppressive immune responses, implying lncRNAs as potential candidates for improving immunotherapy efficacy against tumors and due to the lack of different diagnostic and treatments for glioma, lncRNAs are potential candidates to be used as future diagnostic, prognostic biomarker and treatment tools for glioma. This review’s primary purpose is to concentrate on the role of long non-coding RNAs in early glioma identification, treatment, and immunotherapy. |
format | Online Article Text |
id | pubmed-9127066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91270662022-05-25 The Involvement of Long Non-Coding RNAs in Glioma: From Early Detection to Immunotherapy Wu, Xiaoben Yang, Lei Wang, Jing Hao, Yingying Wang, Changyin Lu, Zhiming Front Immunol Immunology Glioma is a brain tumor that arises in the central nervous system and is categorized according to histology and molecular genetic characteristics. Long non-coding RNAs (lncRNAs) are RNAs longer than 200 nucleotides in length. They have been reported to influence significant events such as carcinogenesis, progression, and increased treatment resistance on glioma cells. Long non-coding RNAs promote cell proliferation, migration, epithelial-to-mesenchymal transition and invasion in glioma cells. Various significant advancements in transcriptomic profiling studies have enabled the identification of immune-related long non-coding RNAs as immune cell-specific gene expression regulators that mediates both stimulatory and suppressive immune responses, implying lncRNAs as potential candidates for improving immunotherapy efficacy against tumors and due to the lack of different diagnostic and treatments for glioma, lncRNAs are potential candidates to be used as future diagnostic, prognostic biomarker and treatment tools for glioma. This review’s primary purpose is to concentrate on the role of long non-coding RNAs in early glioma identification, treatment, and immunotherapy. Frontiers Media S.A. 2022-05-10 /pmc/articles/PMC9127066/ /pubmed/35619711 http://dx.doi.org/10.3389/fimmu.2022.897754 Text en Copyright © 2022 Wu, Yang, Wang, Hao, Wang and Lu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wu, Xiaoben Yang, Lei Wang, Jing Hao, Yingying Wang, Changyin Lu, Zhiming The Involvement of Long Non-Coding RNAs in Glioma: From Early Detection to Immunotherapy |
title | The Involvement of Long Non-Coding RNAs in Glioma: From Early Detection to Immunotherapy |
title_full | The Involvement of Long Non-Coding RNAs in Glioma: From Early Detection to Immunotherapy |
title_fullStr | The Involvement of Long Non-Coding RNAs in Glioma: From Early Detection to Immunotherapy |
title_full_unstemmed | The Involvement of Long Non-Coding RNAs in Glioma: From Early Detection to Immunotherapy |
title_short | The Involvement of Long Non-Coding RNAs in Glioma: From Early Detection to Immunotherapy |
title_sort | involvement of long non-coding rnas in glioma: from early detection to immunotherapy |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127066/ https://www.ncbi.nlm.nih.gov/pubmed/35619711 http://dx.doi.org/10.3389/fimmu.2022.897754 |
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