Cargando…
Morphogenesis of the Mammalian Aortic Arch Arteries
The major vessels in mammals that take blood away from the heart and deliver it to the arms and the head take their origin from the aortic arch and are derived from the arteries formed within the embryonic pharyngeal arches. These pharyngeal arch arteries, initially symmetrical, form in a cranial to...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127140/ https://www.ncbi.nlm.nih.gov/pubmed/35620058 http://dx.doi.org/10.3389/fcell.2022.892900 |
_version_ | 1784712283038941184 |
---|---|
author | Anderson, Robert H. Bamforth, Simon D. |
author_facet | Anderson, Robert H. Bamforth, Simon D. |
author_sort | Anderson, Robert H. |
collection | PubMed |
description | The major vessels in mammals that take blood away from the heart and deliver it to the arms and the head take their origin from the aortic arch and are derived from the arteries formed within the embryonic pharyngeal arches. These pharyngeal arch arteries, initially symmetrical, form in a cranial to caudal sequence within the pharyngeal mesenchyme. They then undergo a complex process of remodeling to produce the asymmetrical brachiocephalic arteries as seen in the adult. A complex interaction between the tissues of the pharyngeal arches and the genes they express is required to ensure that arterial formation and remodeling is able to proceed normally. If this process is disrupted, life-threatening congenital cardiovascular malformations can occur, such as interruption of the aortic arch, isolation of individual arteries, or so-called vascular rings. Here, using state-of-the-art imaging techniques, we describe the morphogenesis of the arteries in humans and mice and the cardiovascular defects in the Tbx1 mutant mouse model. We provide details of the process of remodeling, clarifying also the morphogenesis of the external carotid artery and the so-called “migration” of the left subclavian artery. |
format | Online Article Text |
id | pubmed-9127140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91271402022-05-25 Morphogenesis of the Mammalian Aortic Arch Arteries Anderson, Robert H. Bamforth, Simon D. Front Cell Dev Biol Cell and Developmental Biology The major vessels in mammals that take blood away from the heart and deliver it to the arms and the head take their origin from the aortic arch and are derived from the arteries formed within the embryonic pharyngeal arches. These pharyngeal arch arteries, initially symmetrical, form in a cranial to caudal sequence within the pharyngeal mesenchyme. They then undergo a complex process of remodeling to produce the asymmetrical brachiocephalic arteries as seen in the adult. A complex interaction between the tissues of the pharyngeal arches and the genes they express is required to ensure that arterial formation and remodeling is able to proceed normally. If this process is disrupted, life-threatening congenital cardiovascular malformations can occur, such as interruption of the aortic arch, isolation of individual arteries, or so-called vascular rings. Here, using state-of-the-art imaging techniques, we describe the morphogenesis of the arteries in humans and mice and the cardiovascular defects in the Tbx1 mutant mouse model. We provide details of the process of remodeling, clarifying also the morphogenesis of the external carotid artery and the so-called “migration” of the left subclavian artery. Frontiers Media S.A. 2022-05-10 /pmc/articles/PMC9127140/ /pubmed/35620058 http://dx.doi.org/10.3389/fcell.2022.892900 Text en Copyright © 2022 Anderson and Bamforth. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Anderson, Robert H. Bamforth, Simon D. Morphogenesis of the Mammalian Aortic Arch Arteries |
title | Morphogenesis of the Mammalian Aortic Arch Arteries |
title_full | Morphogenesis of the Mammalian Aortic Arch Arteries |
title_fullStr | Morphogenesis of the Mammalian Aortic Arch Arteries |
title_full_unstemmed | Morphogenesis of the Mammalian Aortic Arch Arteries |
title_short | Morphogenesis of the Mammalian Aortic Arch Arteries |
title_sort | morphogenesis of the mammalian aortic arch arteries |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127140/ https://www.ncbi.nlm.nih.gov/pubmed/35620058 http://dx.doi.org/10.3389/fcell.2022.892900 |
work_keys_str_mv | AT andersonroberth morphogenesisofthemammalianaorticarcharteries AT bamforthsimond morphogenesisofthemammalianaorticarcharteries |