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Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation

Autosomal dominant polycystic kidney disease is the most common monogenic disease that causes end-stage renal failure. It primarily results from mutations in the PKD1 gene that encodes for Polycystin-1. How loss of Polycystin-1 translates into bilateral renal cyst development is mostly unknown. cAMP...

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Detalles Bibliográficos
Autores principales:	Scholz, Julia Katharina, Kraus, Andre, Lüder, Dominik, Skoczynski, Kathrin, Schiffer, Mario, Grampp, Steffen, Schödel, Johannes, Buchholz, Bjoern
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127160/ https://www.ncbi.nlm.nih.gov/pubmed/35620436 http://dx.doi.org/10.1016/j.isci.2022.104359

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