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Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control
BACKGROUND: The functional reorganization of brain networks sustaining gait is poorly characterized in amyotrophic lateral sclerosis (ALS) despite ample evidence of progressive disconnection between brain regions. The main objective of this fMRI study is to assess gait imagery-specific networks in A...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127212/ https://www.ncbi.nlm.nih.gov/pubmed/35598461 http://dx.doi.org/10.1016/j.nicl.2022.103051 |
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author | Abidi, Malek Pradat, Pierre-Francois Termoz, Nicolas Couillandre, Annabelle Bede, Peter de Marco, Giovanni |
author_facet | Abidi, Malek Pradat, Pierre-Francois Termoz, Nicolas Couillandre, Annabelle Bede, Peter de Marco, Giovanni |
author_sort | Abidi, Malek |
collection | PubMed |
description | BACKGROUND: The functional reorganization of brain networks sustaining gait is poorly characterized in amyotrophic lateral sclerosis (ALS) despite ample evidence of progressive disconnection between brain regions. The main objective of this fMRI study is to assess gait imagery-specific networks in ALS patients using dynamic causal modeling (DCM) complemented by parametric empirical Bayes (PEB) framework. METHOD: Seventeen lower motor neuron predominant (LMNp) ALS patients, fourteen upper motor neuron predominant (UMNp) ALS patients and fourteen healthy controls participated in this study. Each subject performed a dual motor imagery task: normal and precision gait. The Movement Imagery Questionnaire (MIQ-rs) and imagery time (IT) were used to evaluate gait imagery in each participant. In a neurobiological computational model, the circuits involved in imagined gait and postural control were investigated by modelling the relationship between normal/precision gait and connection strengths. RESULTS: Behavioral results showed significant increase in IT in UMNp patients compared to healthy controls (P(corrected) < 0.05) and LMNp (P(corrected) < 0.05). During precision gait, healthy controls activate the model's circuits involved in the imagined gait and postural control. In UMNp, decreased connectivity (inhibition) from basal ganglia (BG) to supplementary motor area (SMA) and from SMA to posterior parietal cortex (PPC) is observed. Contrary to healthy controls, DCM detects no cerebellar-PPC connectivity in neither UMNp nor LMNp ALS. During precision gait, bilateral connectivity (excitability) between SMA and BG is observed in the LMNp group contrary to UMNp and healthy controls. CONCLUSIONS: Our findings demonstrate the utility of implementing both DCM and PEB to characterize connectivity patterns in specific patient phenotypes. Our approach enables the identification of specific circuits involved in postural deficits, and our findings suggest a putative excitatory–inhibitory imbalance. More broadly, our data demonstrate how clinical manifestations are underpinned by network-specific disconnection phenomena in ALS. |
format | Online Article Text |
id | pubmed-9127212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-91272122022-05-25 Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control Abidi, Malek Pradat, Pierre-Francois Termoz, Nicolas Couillandre, Annabelle Bede, Peter de Marco, Giovanni Neuroimage Clin Regular Article BACKGROUND: The functional reorganization of brain networks sustaining gait is poorly characterized in amyotrophic lateral sclerosis (ALS) despite ample evidence of progressive disconnection between brain regions. The main objective of this fMRI study is to assess gait imagery-specific networks in ALS patients using dynamic causal modeling (DCM) complemented by parametric empirical Bayes (PEB) framework. METHOD: Seventeen lower motor neuron predominant (LMNp) ALS patients, fourteen upper motor neuron predominant (UMNp) ALS patients and fourteen healthy controls participated in this study. Each subject performed a dual motor imagery task: normal and precision gait. The Movement Imagery Questionnaire (MIQ-rs) and imagery time (IT) were used to evaluate gait imagery in each participant. In a neurobiological computational model, the circuits involved in imagined gait and postural control were investigated by modelling the relationship between normal/precision gait and connection strengths. RESULTS: Behavioral results showed significant increase in IT in UMNp patients compared to healthy controls (P(corrected) < 0.05) and LMNp (P(corrected) < 0.05). During precision gait, healthy controls activate the model's circuits involved in the imagined gait and postural control. In UMNp, decreased connectivity (inhibition) from basal ganglia (BG) to supplementary motor area (SMA) and from SMA to posterior parietal cortex (PPC) is observed. Contrary to healthy controls, DCM detects no cerebellar-PPC connectivity in neither UMNp nor LMNp ALS. During precision gait, bilateral connectivity (excitability) between SMA and BG is observed in the LMNp group contrary to UMNp and healthy controls. CONCLUSIONS: Our findings demonstrate the utility of implementing both DCM and PEB to characterize connectivity patterns in specific patient phenotypes. Our approach enables the identification of specific circuits involved in postural deficits, and our findings suggest a putative excitatory–inhibitory imbalance. More broadly, our data demonstrate how clinical manifestations are underpinned by network-specific disconnection phenomena in ALS. Elsevier 2022-05-17 /pmc/articles/PMC9127212/ /pubmed/35598461 http://dx.doi.org/10.1016/j.nicl.2022.103051 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Abidi, Malek Pradat, Pierre-Francois Termoz, Nicolas Couillandre, Annabelle Bede, Peter de Marco, Giovanni Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control |
title | Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control |
title_full | Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control |
title_fullStr | Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control |
title_full_unstemmed | Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control |
title_short | Motor imagery in amyotrophic lateral Sclerosis: An fMRI study of postural control |
title_sort | motor imagery in amyotrophic lateral sclerosis: an fmri study of postural control |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127212/ https://www.ncbi.nlm.nih.gov/pubmed/35598461 http://dx.doi.org/10.1016/j.nicl.2022.103051 |
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