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Shedding Light on NF-κB Functions in Cellular Organelles

NF-κB is diffusely recognized as a transcriptional factor able to modulate the expression of various genes involved in a broad spectrum of cellular functions, including proliferation, survival and migration. NF-κB is, however, also acting outside the nucleus and beyond its ability to binds to DNA. N...

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Autores principales: Carrà, Giovanna, Avalle, Lidia, Seclì, Laura, Brancaccio, Mara, Morotti, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127296/
https://www.ncbi.nlm.nih.gov/pubmed/35620053
http://dx.doi.org/10.3389/fcell.2022.841646
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author Carrà, Giovanna
Avalle, Lidia
Seclì, Laura
Brancaccio, Mara
Morotti, Alessandro
author_facet Carrà, Giovanna
Avalle, Lidia
Seclì, Laura
Brancaccio, Mara
Morotti, Alessandro
author_sort Carrà, Giovanna
collection PubMed
description NF-κB is diffusely recognized as a transcriptional factor able to modulate the expression of various genes involved in a broad spectrum of cellular functions, including proliferation, survival and migration. NF-κB is, however, also acting outside the nucleus and beyond its ability to binds to DNA. NF-κB is indeed found to localize inside different cellular organelles, such as mitochondria, endoplasmic reticulum, Golgi and nucleoli, where it acts through different partners in mediating various biological functions. Here, we discuss the relationship linking NF-κB to the cellular organelles, and how this crosstalk between cellular organelles and NF-κB signalling may be evaluated for anticancer therapies.
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spelling pubmed-91272962022-05-25 Shedding Light on NF-κB Functions in Cellular Organelles Carrà, Giovanna Avalle, Lidia Seclì, Laura Brancaccio, Mara Morotti, Alessandro Front Cell Dev Biol Cell and Developmental Biology NF-κB is diffusely recognized as a transcriptional factor able to modulate the expression of various genes involved in a broad spectrum of cellular functions, including proliferation, survival and migration. NF-κB is, however, also acting outside the nucleus and beyond its ability to binds to DNA. NF-κB is indeed found to localize inside different cellular organelles, such as mitochondria, endoplasmic reticulum, Golgi and nucleoli, where it acts through different partners in mediating various biological functions. Here, we discuss the relationship linking NF-κB to the cellular organelles, and how this crosstalk between cellular organelles and NF-κB signalling may be evaluated for anticancer therapies. Frontiers Media S.A. 2022-05-10 /pmc/articles/PMC9127296/ /pubmed/35620053 http://dx.doi.org/10.3389/fcell.2022.841646 Text en Copyright © 2022 Carrà, Avalle, Seclì, Brancaccio and Morotti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Carrà, Giovanna
Avalle, Lidia
Seclì, Laura
Brancaccio, Mara
Morotti, Alessandro
Shedding Light on NF-κB Functions in Cellular Organelles
title Shedding Light on NF-κB Functions in Cellular Organelles
title_full Shedding Light on NF-κB Functions in Cellular Organelles
title_fullStr Shedding Light on NF-κB Functions in Cellular Organelles
title_full_unstemmed Shedding Light on NF-κB Functions in Cellular Organelles
title_short Shedding Light on NF-κB Functions in Cellular Organelles
title_sort shedding light on nf-κb functions in cellular organelles
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127296/
https://www.ncbi.nlm.nih.gov/pubmed/35620053
http://dx.doi.org/10.3389/fcell.2022.841646
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