Cargando…

Potential of Natural Alkaloids From Jadwar (Delphinium denudatum) as Inhibitors Against Main Protease of COVID-19: A Molecular Modeling Approach

The ongoing pandemic coronavirus disease (COVID-19) caused by a novel corona virus, namely, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has had a major impact on global public health. COVID-19 cases continue to increase across the globe with high mortality rates in immunocompromise...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Anuj, Sharma, Mansi, Richardson, Christopher D., Kelvin, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127362/ https://www.ncbi.nlm.nih.gov/pubmed/35620478 http://dx.doi.org/10.3389/fmolb.2022.898874

Ejemplares similares

Experimental study of the morphine de-addiction properties of Delphinium denudatum Wall.
por: Rahman, Syed, et al.
Publicado: (2002)

In Vivo Psychopharmacological Investigation of Delphinium Denudatum and Amaranthus Spinosus Extracts on Wistar Rats
por: Abid, Mohammad, et al.
Publicado: (2017)

Isolation, crystal structure determination and cholinesterase inhibitory potential of isotalatizidine hydrate from Delphinium denudatum
por: Ahmad, Hanif, et al.
Publicado: (2016)

In silico Screening of Natural Compounds as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike RBD: Targets for COVID-19
por: Teli, Divya M., et al.
Publicado: (2021)

Computational Repurposing of Drugs and Natural Products Against SARS-CoV-2 Main Protease (M(pro)) as Potential COVID-19 Therapies
por: Piplani, Sakshi, et al.
Publicado: (2022)

Phytochemicals of Euphorbia hirta L. and Their Inhibitory Potential Against SARS-CoV-2 Main Protease
por: Cayona, Ruel, et al.
Publicado: (2022)

Prospective Role of Peptide-Based Antiviral Therapy Against the Main Protease of SARS-CoV-2
por: Mahmud, Shafi, et al.
Publicado: (2021)

A Computer-Aided Approach for the Discovery of D-Peptides as Inhibitors of SARS-CoV-2 Main Protease
por: Hernández González, Jorge E., et al.
Publicado: (2022)

Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus
por: Shan, Lian-Hai, et al.
Publicado: (2017)

Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19
por: Cui, Wen, et al.
Publicado: (2020)

Molecular Mechanisms of HIV Protease Inhibitors Against HPV-Associated Cervical Cancer: Restoration of TP53 Tumour Suppressor Activities
por: Makgoo, Lilian, et al.
Publicado: (2022)

Ligand-based pharmacophore modeling and QSAR approach to identify potential dengue protease inhibitors
por: Poola, Anushka A., et al.
Publicado: (2023)

Evaluation of Clove Phytochemicals as Potential Antiviral Drug Candidates Targeting SARS-CoV-2 Main Protease: Computational Docking, Molecular Dynamics Simulation, and Pharmacokinetic Profiling
por: Chandra Manivannan, Arun, et al.
Publicado: (2022)

An Integrated Computational and Experimental Approach to Identifying Inhibitors for SARS-CoV-2 3CL Protease
por: Zhai, Tianhua, et al.
Publicado: (2021)

A Potential Peptide From Soy Cheese Produced Using Lactobacillus delbrueckii WS4 for Effective Inhibition of SARS-CoV-2 Main Protease and S1 Glycoprotein
por: Chourasia, Rounak, et al.
Publicado: (2020)

In Vitro and In Silico Investigation of Diterpenoid Alkaloids Isolated from Delphinium chitralense
por: Ahmad, Shujaat, et al.
Publicado: (2022)

Regulation of ADAMTS Proteases
por: Rose, Keron W. J., et al.
Publicado: (2021)

Insights Into Dynamics of Inhibitor and Ubiquitin-Like Protein Binding in SARS-CoV-2 Papain-Like Protease
por: Bosken, Yuliana K., et al.
Publicado: (2020)

Disruption of DYRK1A-induced hyperphosphorylation of amyloid-beta and tau protein in Alzheimer’s disease: An integrative molecular modeling approach
por: Shukla, Rohit, et al.
Publicado: (2023)

Multifunctional Mitochondrial AAA Proteases
por: Glynn, Steven E.
Publicado: (2017)

Computational study of nitro-benzylidene phenazine as dengue virus-2 NS2B-NS3 protease inhibitor
por: Salin, Nurul Hanim, et al.
Publicado: (2022)

Validation of Deep Learning-Based DFCNN in Extremely Large-Scale Virtual Screening and Application in Trypsin I Protease Inhibitor Discovery
por: Zhang, Haiping, et al.
Publicado: (2022)

Combining docking, molecular dynamics simulations, AD-MET pharmacokinetics properties, and MMGBSA calculations to create specialized protocols for running effective virtual screening campaigns on the autoimmune disorder and SARS-CoV-2 main protease
por: Edache, Emmanuel Israel, et al.
Publicado: (2023)

Inhibition of SARS-CoV-2 3CL M(pro) by Natural and Synthetic Inhibitors: Potential Implication for Vaccine Production Against COVID-19
por: Ullah, Anwar, et al.
Publicado: (2021)

Mitochondrial Chaperones and Proteases in Cardiomyocytes and Heart Failure
por: Chen, Zee, et al.
Publicado: (2021)

Functions and evolution of FAM111 serine proteases
por: Welter, Allison L., et al.
Publicado: (2022)

Identification of Potential Inhibitors of 3CL Protease of SARS-CoV-2 From ZINC Database by Molecular Docking-Based Virtual Screening
por: Abdusalam, Ashraf Ahmed Ali, et al.
Publicado: (2020)

Unveiling antiplasmodial alkaloids from a cumulative collection of Strychnos extracts by multi-informative molecular networks
por: Bonnet, Olivier, et al.
Publicado: (2022)

Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis
por: Elsholz, Alexander K. W., et al.
Publicado: (2017)

Control of Toxin-Antitoxin Systems by Proteases in Mycobacterium Tuberculosis
por: Bordes, Patricia, et al.
Publicado: (2021)

Unraveling the Dichotomy of Enigmatic Serine Protease HtrA2
por: Chakraborty, Ayon, et al.
Publicado: (2022)

Cellular functions of the ClpP protease impacting bacterial virulence
por: Aljghami, Mazen E., et al.
Publicado: (2022)

DNA accelerates the protease inhibition of a bacterial serpin chloropin
por: Xu, Jiawei, et al.
Publicado: (2023)

Tuftsin: A Natural Molecule Against SARS-CoV-2 Infection
por: Huang, Jiahao, et al.
Publicado: (2022)

Diterpenoid Alkaloids Isolated from Delphinium brunonianum and Their Inhibitory Effects on Hepatocytes Lipid Accumulation
por: Ma, Huanhuan, et al.
Publicado: (2022)

COVID-19: Targeting Proteases in Viral Invasion and Host Immune Response
por: Seth, Sanchit, et al.
Publicado: (2020)

Editorial: ADAM, ADAMTS and Astacin Proteases: Challenges and Breakthroughs in the -Omics Era
por: Yamamoto, Kazuhiro, et al.
Publicado: (2021)

A Conserved Mitochondrial Chaperone-Protease Complex Involved in Protein Homeostasis
por: Serricchio, Mauro, et al.
Publicado: (2021)

Utilization of Mechanistic Enzymology to Evaluate the Significance of ADP Binding to Human Lon Protease
por: Fishovitz, Jennifer, et al.
Publicado: (2017)

Host Serine Proteases: A Potential Targeted Therapy for COVID-19 and Influenza
por: Rahbar Saadat, Yalda, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jipc0pqstos46mpqorghhun1vf