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2-Aminoacrylate stress damages diverse PLP-dependent enzymes in vivo

Pyridoxal 5′-phosphate (PLP) is an essential cofactor for a class of enzymes that catalyze diverse reactions in central metabolism. The catalytic mechanism of some PLP-dependent enzymes involves the generation of reactive enamine intermediates like 2-aminoacrylate (2AA). 2AA can covalently modify PL...

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Detalles Bibliográficos
Autores principales:	Shen, Wangchen, Borchert, Andrew J., Downs, Diana M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127364/ https://www.ncbi.nlm.nih.gov/pubmed/35460692 http://dx.doi.org/10.1016/j.jbc.2022.101970

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