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Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN

The protease SPRTN degrades DNA-protein crosslinks (DPCs) that threaten genome stability. SPRTN has been connected to the ubiquitin-directed protein unfoldase p97 (also called VCP or Cdc48), but a functional cooperation has not been demonstrated directly. Here, we biochemically reconstituted p97-ass...

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Detalles Bibliográficos
Autores principales:	Kröning, Alexander, van den Boom, Johannes, Kracht, Matthias, Kueck, Anja F., Meyer, Hemmo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127365/ https://www.ncbi.nlm.nih.gov/pubmed/35469923 http://dx.doi.org/10.1016/j.jbc.2022.101976

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