AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4

Valosin-containing protein (VCP) is a member of AAA-ATPase superfamily involved in various cellular functions. To investigate the pathophysiological role of VCP in metabolic disorders, we generated knock-in mice bearing an A232E mutation in VCP, a known human VCP pathogenic variant. When heterozygou...

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Detalles Bibliográficos
Autores principales: Shibuya, Koji, Ebihara, Ken, Ebihara, Chihiro, Sawayama, Nagisa, Isoda, Masayo, Yamamuro, Daisuke, Takahashi, Manabu, Nagashima, Shuichi, Ishibashi, Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127370/
https://www.ncbi.nlm.nih.gov/pubmed/35430252
http://dx.doi.org/10.1016/j.jbc.2022.101936

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