Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK

Activated Cdc42-associated kinase (ACK) is an oncogenic nonreceptor tyrosine kinase associated with poor prognosis in several human cancers. ACK promotes proliferation, in part by contributing to the activation of Akt, the major effector of class 1A phosphoinositide 3-kinases (PI3Ks), which transduc...

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Detalles Bibliográficos
Autores principales: Clayton, Natasha S., Fox, Millie, Vicenté-Garcia, Jose J., Schroeder, Courtney M., Littlewood, Trevor D., Wilde, Jonathon I., Krishnan, Kadalmani, Brown, Murray J.B., Crafter, Claire, Mott, Helen R., Owen, Darerca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127371/
https://www.ncbi.nlm.nih.gov/pubmed/35429500
http://dx.doi.org/10.1016/j.jbc.2022.101916

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