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Generation of human parallel chimeric antigen receptor (pCAR) T cells to achieve synergistic T cell co-stimulation

Dual co-stimulation may be harnessed using parallel chimeric antigen receptors (pCARs) in which two distinct co-stimulatory units are adjacently localized on the plasma membrane. This protocol summarizes construct design, human T cell isolation, retroviral transduction, tissue culture expansion, and...

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Detalles Bibliográficos
Autores principales:	Larcombe-Young, Daniel, Whilding, Lynsey, Davies, David Marc, Draper, Benjamin, Bechman, Natasha, Maher, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127424/ https://www.ncbi.nlm.nih.gov/pubmed/35620078 http://dx.doi.org/10.1016/j.xpro.2022.101414

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